Auto-antibodies (auto-abs) to type I interferons (IFNs) have been identified in patients with life-threatening coronavirus disease 2019 (COVID-19), suggesting that the presence of auto-abs may be a risk factor for disease seve...
Cancer research communications 4(2) 446-459 Feb 2024 [Refereed]
UNLABELLED: Invariant natural killer T (iNKT) cells play an essential role in antitumor immunity by exerting cytotoxicity and producing massive amounts of cytokines. iNKT cells express invariant T-cell receptors (TCR) to recognize their cognate gl...
Ryo Koyama-Nasu   Motoko Y Kimura   Masahiro Kiuchi   Ami Aoki   Yangsong Wang   Yukiyoshi Mita   Ichita Hasegawa   Yukihiro Endo   Atsushi Onodera   Kiyoshi Hirahara   Shinichiro Motohashi   Toshinori Nakayama   
Cancer immunology research May 2023 [Refereed]
Tumor-specific CD8+ T cells play a pivotal role in anti-tumor immunity and are a key target of immunotherapeutic approaches. Intratumoral CD8+ T cells are heterogeneous; Tcf1+ stem-like CD8+ T cells give rise to their cytotoxic progeny - Tim-3+ te...
Hiroshi Yuita   Isaac F López-Moyado   Hyeongmin Jeong   Arthur Xiuyuan Cheng   James Scott-Browne   Jungeun An   Toshinori Nakayama   Atsushi Onodera   Myunggon Ko   Anjana Rao   
Proceedings of the National Academy of Sciences of the United States of America 120(6) e2214824120 Feb 2023 [Refereed]
The three mammalian TET dioxygenases oxidize the methyl group of 5-methylcytosine in DNA, and the oxidized methylcytosines are essential intermediates in all known pathways of DNA demethylation. To define the in vivo consequences of complete TET d...
-Japan Society for the Promotion of Science: Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (B)
Project Year: Apr 2022 - Mar 2025
-Japan Society for the Promotion of Science: Grants-in-Aid for Scientific Research Fund for the Promotion of Joint International Research (Fostering Joint International Research (A))
Project Year: 2021 - 2022
Active and passive DNA demethylation in T cellsJapan Society for the Promotion of Science: Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (C)Onodera Atsushi 
Project Year: Apr 2018 - Mar 2021
Elucidation of pathogenic immune memory formation and maintenanceJapan Society for the Promotion of Science: Grants-in-Aid for Scientific ResearchNakayama Toshinori HIRAHARA kiyoshi KIMURA motoko ONODERA atsushi KIUCHI masahiro HOSOKAWA hiroyuki SHINODA kenta ENDO yusuke