Department of Artificial Intelligence Medicine, Graduate School of Medicine, Karolinska Institutet Department of Biosciences and Nutrition, Osaka University Premium Research Institute for Human Metaverse Medicine (PRIMe)
Research funding number
70807065
ORCID ID
0000-0002-8915-9282
J-Global ID
201501005591850405
Research Interests
induced pluripotent stem cells
,Stem cells
,regenerative medicine
,Transcriptome
,Bioinformatics
Research Areas
Life sciences / Systems genomics /
Informatics / Biological, health, and medical informatics / Bioinformatics
Andrea Coschiera Masahito Yoshihara Gilbert Lauter Sini Ezer Mariangela Pucci Haonan Li Alan Kavšek Christian G Riedel Juha Kere Peter Swoboda
BMC biology 22(1) 48-48 Feb 2024 [Refereed]
BACKGROUND: Primary cilia emanate from most human cell types, including neurons. Cilia are important for communicating with the cell's immediate environment: signal reception and transduction to/from the ciliated cell. Deregulation of ciliary sign...
Embryonic genome activation (EGA) is a critical step in embryonic development. However, while EGA has been studied in mice using mouse 2-cell-like cells, human EGA remains incompletely elucidated due to the lack of an in vitro cell model recapitul...
Daniel F Kaemena Masahito Yoshihara Meryam Beniazza James Ashmore Suling Zhao Mårten Bertenstam Victor Olariu Shintaro Katayama Keisuke Okita Simon R Tomlinson Kosuke Yusa Keisuke Kaji
Nature communications 14(1) 488-488 Jan 2023 [Refereed]
Induced pluripotent stem cell (iPSC) reprogramming is inefficient and understanding the molecular mechanisms underlying this inefficiency holds the key to successfully control cellular identity. Here, we report 24 reprogramming roadblock genes ide...
Masahito Yoshihara Magdalena Wagner Anastasios Damdimopoulos Cheng Zhao Sophie Petropoulos Shintaro Katayama Juha Kere Fredrik Lanner Pauliina Damdimopoulou
Ovaries are central to development, fertility, and reproduction in women. A particularly interesting feature of ovaries is their accelerated ageing compared to other tissues, leading to loss of function far before other organs senesce. The limited...
Masahito Yoshihara Ida Kirjanov Sonja Nykänen Joonas Sokka Jere Weltner Karolina Lundin Lisa Gawriyski Eeva-Mari Jouhilahti Markku Varjosalo Mari H Tervaniemi Timo Otonkoski Ras Trokovic Shintaro Katayama Sanna Vuoristo Juha Kere
DUX4 has recently been recognized as a key regulator in human embryonic genome activation (EGA). The exact role of DUX4 in human embryo is still elusive, partly due to the cytotoxicity of persistent <italic>DUX4</italic> expression in cellular mod...
Karolinska Institutet - RIKEN Joint International Doctoral Course 2018 "Bioinformatics analysis of gene regulation in omics data and its applications to medical problems” 7 Mar 2018 [Invited]
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