医学部附属病院

山中 義崇

ヤマナカ ヨシタカ  (Yoshitaka YAMANAKA)

基本情報

所属
千葉大学 医学部附属病院 浦安リハビリテーション教育センター 特任教授
学位
医学博士(千葉大学)

J-GLOBAL ID
201801015495475552
researchmap会員ID
B000346979

学歴

 3

論文

 88
  • Yoshikazu Nakano, Shigeki Hirano, Mitsuyoshi Tamura, Yume Koizumi, Yoshihisa Kitayama, Michiko Izumi, Masahide Suzuki, Kosuke Yamagishi, Yutaro Suzuki, Shinobu Ikeda, Ayaka Arase, Tatsuya Yamamoto, Yoshitaka Yamanaka, Atsuhiko Sugiyama, Kazumoto Shibuya, Takuro Horikoshi, Takashi Uno, David Eidelberg, Satoshi Kuwabara
    Scientific reports 15(1) 8056-8056 2025年3月7日  
    Rigidity, a cardinal symptom of Parkinson's disease (PD), remains challenging to assess objectively. A torque-angle instrument was developed to quantify muscle tone, providing two parameters: bias difference and elastic coefficient. This study aimed to investigate the association of the instrument-measured rigidity with clinical assessments and brain function. In 30 patients with PD, the muscle tone in both arms was evaluated. Ten with wearing-off phenomenon were assessed twice, off and on condition. Twentynine patients underwent brain perfusion single-photon emission computed tomography (SPECT), and expression of PD-related covariance pattern (PDRP) was computed. Bias difference and elastic coefficient showed positive correlations with physician-rated rigidity (P < 0.002). Bias difference decreased after dopaminergic medication (P = 0.022) and was associated with lower body mass index (P = 0.012). Elastic coefficient positively correlated with the Unified PD Rating Scale Part III and PDRP scores (P < 0.044). Furthermore, the higher bias difference correlated with decreased sensory-motor cortex and increased substantia nigra perfusion (P < 0.001). The Torque-angle instrument is a viable tool for quantifying rigidity in PD. The bias difference reflects treatment responsiveness and is associated with the function in the sensory-motor cortex and substantia nigra. The elastic coefficient is indicative of overall Parkinsonism severity.
  • 荒木 信之, 山中 義崇, 中嶋 秀人, 桑原 聡
    臨床神経学 64(Suppl.) S320-S320 2024年10月  
  • 小泉 湧芽, 平野 成樹, 山本 達也, 山中 義崇, 荒木 信之, 杉山 淳比古, 櫻井 透, 仲野 義和, 堀越 琢郎, 飯森 隆志, 北山 仁久, 和泉 未知子, 田村 光至, 山岸 航介, 桑原 聡
    臨床神経学 64(Suppl.) S324-S324 2024年10月  
  • 荒井 夏海, 黒岩 良太, 澁谷 和幹, 奈良 猛, 森田 光生, 諸岡 茉里恵, 安田 真人, 鵜沢 顕之, 山中 義崇, 桑原 聡, 村田 淳
    臨床神経学 64(Suppl.) S432-S432 2024年10月  
  • Jiaqi Wang, Atsuhiko Sugiyama, Hajime Yokota, Shigeki Hirano, Tatsuya Yamamoto, Yoshitaka Yamanaka, Nobuyuki Araki, Shoichi Ito, Friedemann Paul, Satoshi Kuwabara
    Diagnostics 14(2) 201-201 2024年1月17日  
    Multiple system atrophy with predominant parkinsonism (MSA-P) can hardly be distinguished from Parkinson’s disease (PD) clinically in the early stages. This study investigated whether a standardized T1-weighted/T2-weighted ratio (sT1w/T2w ratio) can effectively detect degenerative changes in the middle cerebellar peduncle (MCP) associated with MSA-P and PD and evaluated its potential to distinguish between these two diseases. We included 35 patients with MSA-P, 32 patients with PD, and 17 controls. T1w and T2w scans were acquired using a 1.5-T MR system. The MCP sT1w/T2w ratio was analyzed via SPM12 using a region-of-interest approach in a normalized space. The diagnostic performance of the MCP sT1w/T2w ratio was compared between the MSA-P, PD, and controls. Patients with MSA-P had significantly lower MCP sT1w/T2w ratios than patients with PD and controls. Furthermore, MCP sT1w/T2w ratios were lower in patients with PD than in the controls. The MCP sT1w/T2w ratio showed excellent or good accuracy for differentiating MSA-P or PD from the control (area under the curve (AUC) = 0.919 and 0.814, respectively) and substantial power for differentiating MSA-P from PD (AUC = 0.724). Therefore, the MCP sT1w/T2w ratio is sensitive in detecting degenerative changes in the MCP associated with MSA-P and PD and is useful in distinguishing MSA-P from PD.

MISC

 341

書籍等出版物

 2

担当経験のある科目(授業)

 1

共同研究・競争的資金等の研究課題

 1

社会貢献活動

 9