子どものこころの発達教育研究センター
基本情報
- 所属
- 千葉大学 千葉大学子どものこころの発達教育研究センター 特任助教(兼任)国際未来教育基幹 特任助教
- 学位
- 学士（医学）(2016年3月 千葉大学)博士（医学）(2025年3月 千葉大学)
- 研究者番号
- 50963550
- J-GLOBAL ID
- 202201003304109742
- researchmap会員ID
- R000036911
研究分野
1論文
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medRxiv : the preprint server for health sciences 2024年11月7日Previous studies have suggested that alterations in white matter (WM) microstructure are implicated in suicidal thoughts and behaviours (STBs). However, findings of diffusion tensor imaging (DTI) studies have been inconsistent. In this large-scale mega-analysis conducted by the ENIGMA Suicidal Thoughts and Behaviours (ENIGMA-STB) consortium, we examined WM alterations associated with STBs. Data processing was standardised across sites, and resulting WM microstructure measures (fractional anisotropy, axial diffusivity, mean diffusivity and radial diffusivity) for 25 WM tracts were pooled across 40 cohorts. We compared these measures among individuals with a psychiatric diagnosis and lifetime history of suicide attempt (n=652; mean age=35.4±14.7; female=71.8%), individuals with a psychiatric diagnosis but no STB (i.e., clinical controls; n=1871; mean age=34±14.8; female=59.8%), and individuals with no mental disorder diagnosis and no STB (i.e., healthy controls; n=642; mean age=29.6±13.1; female=62.9%). We also compared these measures among individuals with recent suicidal ideation (n=714; mean age=36.3±15.3; female=66.1%), clinical controls (n=1184; mean age=36.8±15.6; female=63.1%), and healthy controls (n=1240; mean age= 31.6±15.5; female=61.0%). We found subtle but statistically significant effects, such as lower fractional anisotropy associated with a history of suicide attempt, over and above the effect of psychiatric diagnoses. These effects were strongest in the corona radiata, thalamic radiation, fornix/stria terminalis, corpus callosum and superior longitudinal fasciculus. Effect sizes were small (Cohen's d < 0.25). Recent suicidal ideation was not associated with alterations in WM microstructure. This large-scale coordinated mega-analysis revealed subtle regional and global alterations in WM microstructure in individuals with a history of suicide attempt. Longitudinal studies are needed to confirm whether these alterations are a risk factor for suicidal behaviour.
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Cureus 16(1) e52953 2024年1月We describe the case of an unvaccinated 21-year-old Japanese male who experienced psychotic symptoms attributed to encephalopathy, known as post-acute COVID-19 syndrome (PACS). One week after his discharge following the remission of a SARS-CoV-2 infection, he experienced hyperactive delirium and unexpected movements of his limbs. As COVID-19-associated encephalopathy was suspected as a cause of the psychotic symptoms, he was admitted to the Department of Neurology. He received antiviral and steroid pulse therapy, but his psychiatric symptoms did not improve completely. Consequently, he was admitted to our psychiatric ward with a diagnosis of a primary psychotic disorder. Although he did not take psychopharmacotherapy, he gradually achieved a remission of psychiatric symptoms. At three months post-SARS-CoV-2 infection, single-photon emission computed tomography (SPECT) revealed hypoperfusion in the bilateral cerebellar dentate nuclei and occipital lobes. However, no abnormal findings were observed on fluorine-18 fluoro-deoxy-glucose positron emission tomography (18F-FDG PET) at six months after the infection. This case indicates that (1) brain perfusion SPECT can be effective for detecting functional alterations in post-acute COVID-19-associated encephalopathy, and (2) it is necessary to carefully monitor patients' progress instead of quickly diagnosing a primary psychotic disorder.
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Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine 18(5) 1459-1462 2022年1月13日Lemborexant is a dual orexin antagonist (DORA) and is considered a safe and effective hypnotic. DORAs induce physiological sleep by blocking orexin receptors. Although the blockade of orexin signaling has triggered narcolepsy-like symptoms in rodents, there is currently no evidence of lemborexant inducing narcolepsy-like symptoms in humans. We describe the case of a 79-year-old Japanese woman with bipolar depression who experienced lemborexant-induced cataplexy and sleep attack. Her previous results on the Multiple Sleep Latency Test excluded the diagnosis of narcolepsy. She experienced narcolepsy-like symptoms on two occasions after she was administered lemborexant, in the context of hyperactive delirium, but not in a relaxed state. Her case suggests that lemborexant could trigger narcolepsy-like symptoms in patients with hyperactive delirium, even those with no history of narcolepsy. This case also emphasizes that clinicians must be very careful when they prescribe lemborexant to patients who experience hyperactive delirium.
MISC
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子どものこころと脳の発達 15(1) 63-69 2024年12月児童生徒の自殺予防に係る取組として,WEBでの子どものストレスチェックを推進している.現時点で,学校長,教頭,副校長,学年主任,担任等が職員会議,教育相談部会で子どものストレスチェックの実施の情報共有を行い,教育相談担当教員が中心となり,実施する学校が多い.今後は,2次予防の健康診断のように学校医が養護教諭とともに,1次予防の子どものストレスチェックを実施する形や保健体育の教員が保健体育の「心身の相関とストレス」単元等の授業の中でアクティブ・ラーニングとして活用する形も期待している.ストレス対処法である認知行動療法を活用し,不登校の児童生徒等が登校再開する際の3次予防として,復帰支援,再発予防にも取り組むべきである.政策提言として,いじめの認知件数のように,高ストレス児童生徒の認知件数を全国の小・中・高等学校及び特別支援学校から文部科学省がデータ収集し,自殺対策に活用していただきたいと考えている.(著者抄録)
講演・口頭発表等
13所属学協会
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共同研究・競争的資金等の研究課題
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日本学術振興会 科学研究費助成事業 基盤研究(C) 2023年4月 - 2026年3月