医学部附属病院

向井 宏樹

ムカイ ヒロキ  (Hiroki Mukai)

基本情報

所属
千葉大学 医学部附属病院 助教
学位
医学博士(2016年3月 千葉大学)

研究者番号
70748748
J-GLOBAL ID
202201005925815007
researchmap会員ID
R000032803

論文

 40
  • Sakie Namba, Hajime Yokota, Hiroki Mukai, Jun Hashiba, Naoki Kogayo, Tatsushi Nakao, Atsuhiko Sugiyama, Etsuko Ogaya, Yuya Aotsuka, Satoshi Kuwabara, Takashi Uno
    Radiology case reports 19(5) 1718-1721 2024年5月  
    We report the case of a woman in her 40s who presented with sensory disturbances in all 4 limbs and left facial palsy. MRI revealed asymmetric enlargement of the dorsal root ganglia, which was enhanced by gadolinium-a chest CT scan identified enlarged supraclavicular, mediastinal, and hilar lymph nodes. A biopsy of a hilar lymph node showed noncaseating epithelioid granulomas, confirming a sarcoidosis diagnosis. Prednisolone treatment led to symptomatic improvements. In sarcoidosis of the peripheral nervous system, there might be observable enlargement of the dorsal root ganglion alongside enhanced gadolinium contrast. Obtaining a biopsy from the dorsal root ganglion poses challenges, and radiologists should be mindful of this specific imaging characteristic.
  • Yuki Muroga, Atsuhiko Sugiyama, Hiroki Mukai, Jun Hashiba, Hajime Yokota, Katsuya Satoh, Tetsuyuki Kitamoto, Jiaqi Wang, Shoichi Ito, Satoshi Kuwabara
    Prion 17(1) 105-110 2023年12月  
    The most common genetic Creutzfeldt-Jakob disease (gCJD) in Japan is caused by a point mutation in which isoleucine replaces valine at codon 180 of the prion protein (PrP) gene (V180I gCJD). Evidence suggests that cerebral cortex swelling, which appears as abnormal hyperintensities on diffusion-weighted imaging (DWI), is a characteristic magnetic resonance imaging (MRI) finding of V180I gCJD. However, no study has directly compared the MRI findings between V180I gCJD and sporadic CJD (sCJD). The current study, therefore, aims to clarify the imaging features of V180I gCJD, which would lead to prompt genetic counselling and analysis of the PrP gene, particularly focusing on cerebral cortex swelling. We included 35 patients with sCJD (n = 23) or V180I gCJD (n = 12). Cerebral cortex swelling on T2-weighted imaging (T2WI) or fluid-attenuated inversion recovery (FLAIR) wherein abnormal cortical hyperintensities were observed on DWI, and the distribution of grey matter hyperintensities on DWI were visually evaluated. V180I gCJD patients had significantly more cerebral cortex swelling (100% vs. 13.0%, p < 0.001), an overall correct classification of 91.4%, and parahippocampal gyrus hyperintensities on DWI (100% vs. 39.1%, q = 0.019) than sCJD patients. Cerebral cortical hyperintensities on DWI with swelling on T2WI or FLAIR are characteristic imaging findings of V180I gCJD and are useful for differentiating it from sCJD.
  • 羽柴 淳, 服部 真也, 向井 宏樹, 横田 元
    日本小児放射線学会雑誌 39(Suppl.) 44-44 2023年5月  
  • 前島 拓馬, 堀越 琢郎, 向井 宏樹, 那須 克宏, 中島 裕史, 松坂 恵介, 池田 純一郎, 宇野 隆
    臨床放射線 68(3) 309-311 2023年3月  

MISC

 88