研究者業績

川嶋 大介

カワシマ ダイスケ  (Daisuke Kawashima)

基本情報

所属
千葉大学 大学院工学研究院 助教
学位
博士(工学)(首都大学東京)

研究者番号
10813785
ORCID ID
 https://orcid.org/0000-0002-1523-6206
J-GLOBAL ID
201901014677336443
researchmap会員ID
B000349507

論文

 54
  • Soichiro Ueno, Daisuke Kawashima, Katsuhiro Matsuura, Hiromichi Obara, Ryou Tanaka, Masahiro Takei
    Bioelectrochemistry 163 2025年6月  査読有り責任著者
    Heparin concentration c in a blood extracorporeal circulation has been real-timely predicted based on the relaxation strength Δεm at relaxation frequency fm extracted by relaxation time distribution (RTD). The simulated extracorporeal circulation was conducted to optimize the number of Δεm for the prediction of c using the porcine whole blood (WB) and low-leukocyte and −platelet blood (LLPB) under the condition of the gradual increment of c from 0 to 8 U/mL with constant flow rate and blood temperature. The experimental results show that among the three relaxation strengths Δε1, Δε2 and Δε3 (in ascending order of frequency), Δε2 at f2 = 5.2 ∼ 6.2 MHz and Δε3 at f3 = 42 ∼ 50 MHz were correlated to c. The Δε3 was decreasing with increasing c in both cases, which was influenced by the plasma macromolecular concentrations, while the Δε2 was increased with increasing c in WB case but was hardly changed in LLPB case because the Δε2 is influenced by the blood cell concentrations and the shape changes of blood cell membranes. Heparin concentration c is estimated by the linear regression formula cPRE=a1(Δε2-Δε2c=0)+a2(Δε3-Δε3c=0) (a1 = -0.991, a2 = -0.123) within the mean absolute percentage error (MAPE) of 0.291.
  • Arbariyanto Mahmud Wicaksono, Daisuke Kawashima, Ryoma Ogawa, Shinsuke Akita, Masahiro Takei
    Biomedical physics & engineering express 11(2) 2025年1月31日  査読有り責任著者
    Albumin andγ-globulin concentrations in subcutaneous adipose tissues (SAT) have been quantified by multivariate regression based on admittance relaxation time distribution (mrARTD) under the fluctuated background of sodium electrolyte concentration. ThemrARTD formulatesP=Ac+Ξ(P: peak matrix of distribution function magnitudeγˆand relaxation timesτˆ,c: concentration matrix of albumincAlb,γ-globulinGloc, and sodium electrolyteNac,A: coefficient matrix of a multivariate regression model, andΞ: error matrix). ThemrARTD is implemented by two processes which are: (1) the training process ofAthrough the maximum likelihood estimation ofPand (2) the quantification process ofcAlb,Gloc, andNacthrough the model prediction. In the training process, a positive correlation is present betweencAlb,Gloc, andNactoγˆ1atτˆ1= 0.1 as well asγˆ2atτˆ2= 1.40 μs as under a fixed concentration of proteins solution into a porcine SAT (cAlb= 0.800-2.400 g/dL,Gloc= 0.400-1.200 g dl-1andNac= 0.700-0.750 g dl-1). ThemrARTD method quantifiescAlb,Gloc, andNacin SAT with an absolute error of 33.79%, 44.60%, and 2.18%, respectively.
  • Soichiro UENO, Daisuke KAWASHIMA, Katsuhiro MATSUURA, Ryou TANAKA, Masashiro TAKEI
    Transactions of the JSME (in Japanese) 91(942) 24-00208 2025年  
  • 金本泰地, 川嶋大介, Sejati Prima Asmara, Sejati Prima Asmara, 武居昌宏
    粉体工学会誌 61(7) 2024年  査読有り責任著者
  • Daisuke Kawashima, Songshi Li, Hiromichi Obara, Masahiro Takei
    IEEE Transactions on Instrumentation and Measurement 2024年  査読有り筆頭著者
    The multi-frequency complex electrical impedance tomography (mfc-EIT) has been proposed to image the spatiotemporal extra/intra-cellular ion concentrations. In mfc-EIT, four frequency-dependent Jacobian matrices described by the partial derivatives of complex impedance (resistance and reactance) with respect to complex conductivity (conductivity σ and relative permittivity ε) as a function of radial frequency are newly introduced as a complex Jacobian matrix. The mfc-EIT inversely reconstructs the σ and ε images as a function of frequency from the complex impedance. Based on the electric field simulation, the σ and ε images reconstructed by mfc-EIT and conventional EIT with a general Jacobian matrix are evaluated by spectral stabilities <SS> which is an indicator of reasonable spectral trend. The σ and ε images by mfc-EIT have lower <SS> (σ: 2.7 × 10-9 in and ε: 3.0 × 10-4 in) than those by conventional EIT (σ: 5.5 × 10-8 and ε: 5.6 × 10-3), which indicates mfc-EIT reconstructs the reasonable frequency response. The mfc-EIT is also applied to the imaging of the extra/intrace-cellular ion transfer around cell-spheroids in experiment. According to the reconstructed σ and ε images, the extracellular ion concentration reflected by σ at f = 1 kHz are increased over time, while the intracellular ion concentration reflected by σ and ε at f = 1 MHz are decreased over time, which is attributed to the ion transfer via the ion channel. Thus, mfc-EIT captures the extra/intra-cellular ion concentration changes by ion transfer via ion channels.

MISC

 73

書籍等出版物

 6

講演・口頭発表等

 101

共同研究・競争的資金等の研究課題

 8

産業財産権

 2

社会貢献活動

 1