研究者業績

木村 敦史

キムラ アツシ  (Atsushi Kimura)

基本情報

所属
千葉大学 大学院医学研究院精神医学 講師
学位
医学博士(2015年3月 千葉大学)

J-GLOBAL ID
202001019076862736
researchmap会員ID
B000382293

論文

 49
  • Hiroki Ishii, Tasuku Hashimoto, Aiko Sato, Mami Tanaka, Ryota Seki, Michi Ogawa, Atsushi Kimura, Michiko Nakazato, Masaomi Iyo
    Scientific Reports 14(1) 2024年7月15日  
    Abstract Patients with bipolar disorder (BD) and major depressive disorder (MDD) experience psychological distress associated with daily events that do not meet the threshold for traumatic experiences, referred to as event-related psychological distress (ERPD). Recently, we developed an assessment tool for ERPD, the ERPD-24. This tool considers four factors of ERPD: feelings of revenge, rumination, self-denial, and mental paralysis. We conducted a cross-sectional study between March 2021 and October 2022 to identify the differences and clinical features of ERPD among patients with MDD and BD and healthy subjects who did not experience traumatic events. Specifically, we assessed ERPD using the ERPD-24 and anxiety-related symptoms with the State-Trait Anxiety Inventory, Liebowitz Social Anxiety Scale, and anxious-depressive attack. Regarding the ERPD-24 scores among the groups, as the data did not rigorously follow the test of normality, the Kruskal–Wallis test was used to compare the differences among the groups, followed by the Dunn–Bonferroni adjusted post-hoc test. Non-remitted MDD patients and BD patients, regardless of remission/non-remission, presented more severe ERPD than healthy subjects. This study also demonstrated the relationships between all anxiety-related symptoms, including social phobia and anxious-depressive attack and ERPD, in both BD and MDD patients and in healthy subjects. In conclusion, patients with non-remitted MDD and with BD regardless of remission/non-remission experience severe ERPD related to anxiety-related symptoms.
  • Masumi Tachibana, Nobuhisa Kanahara, Yasunori Oda, Tadashi Hasegawa, Atsushi Kimura, Masaomi Iyo
    Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine 2023年12月8日  
    STUDY OBJECTIVES: Although novel hypnotics have recently emerged, there are currently no data comparing the clinical potency of benzodiazepine receptor agonists (BZRAs) and novel hypnotics, or the effectiveness of different methods of switching between them. This study examined how novel hypnotics might help reduce BZRA use in real-world practice. METHODS: 289 patients with psychiatric disorders who took BZRAs for over 1 year before switching to either of two dual-orexin receptor antagonists (DORAs) (suvorexant (SUV) or lemborexant (LEM)) or a melatonin receptor agonist (ramelteon (RMT)) were enrolled. We collected data on BZRAs at baseline and 3 months after commencement of SUV/LEM/RMT. RESULTS: Significant reductions in BZRAs were observed for all three agents: -4.10, -2.80 and -1.65 mg in diazepam-equivalent dose in the SUV, LEM and RMT groups, respectively. Dose reduction was significantly greater in the DORA than the RMT group (F=15.053, P<0.001). Within the DORA group, dose reduction was significantly greater in patients taking SUV than those taking LEM (F=4.337, P=0.043). The switching success rate did not differ among the switching methods for any of the hypnotics. CONCLUSIONS: The reduction rate of BZRAs achieved by the switch fell into their equivalent-potency range estimated from clinical trials. The results suggest that DORAs can replace approximately one tablet of a BZRA. The difference in dose reduction between DORAs and RMT reflected the greater sleeping potency of the DORAs, whereas that between SUV and LEM might have reflected patient backgrounds: patients taking LEM may have been more strongly dependent on BZRAs.
  • 木村 敦史, 新津 富央, 伊豫 雅臣
    精神神経学雑誌 (2023特別号) S586-S586 2023年6月  
  • 御園 覚夫, 島田 侑佳, 須川 裕之, 大木 望, 廣瀬 祐紀, 小田 靖典, 木村 敦史, 長谷川 直, 伊豫 雅臣
    精神神経学雑誌 125(1) 85-85 2023年1月  
  • 小川 道, 橋本 佐, 石井 宏樹, 関 亮太, 佐藤 愛子, 橘 真澄, 木村 敦史, 山崎 香織, 椿 佳那子, 田中 麻未, 佐藤 泰憲, 新津 富央, 中里 道子, 伊豫 雅臣
    日本周産期メンタルヘルス学会学術集会抄録集 18回 93-93 2022年10月  

MISC

 22

共同研究・競争的資金等の研究課題

 1