荒野泰

アラノヤスシ (Yasushi Arano)

基本情報

所属: 千葉大学大学院薬学研究院創薬資源科学教授

学位: 薬学博士

J-GLOBAL ID: 200901078926347702
researchmap会員ID: 1000028673

外部リンク: http://www.p.chiba-u.ac.jp/lab/housha/index.html

研究キーワード

研究分野

学歴

受賞

1992年

日本核医学会賞
1992年

Japanses Society of Nuclear Medicine Award
1982年

世界核医学会賞
1982年

Amasham Prize (The 3rd World Congress of Nuclear Medicine and Biology)

MISC

157

Biological comparison of DTPA and SCN-benzyl-EDTA as chelating agents for indium-labeling of antibodies

Y. Arano, T. Mukai, T. Uezono, H. Motonari, K. Wakisaka, A. Yokoyama

Journal of Labelled Compounds and Radiopharmaceuticals 35 381-383 1994年
Maleimodoethyl 3-(tri-n-butylstannyl)hippurate: A Useful Radioiodination Reagent for Protein Radiopharmaceuticals to Enhance Target Selective Radioactivity Localization.

J. Med. Chem. 37, 2609-2618 1994年
Stabilization of Ester Bond in Plasma to Enhance Target Radioactivity Delivery by Antibody Conjugated with Metallic Radionuclides through Metabolizable Ester Linkage.

J. Labelled Compds. Radiopharm. 32, 391-392 1993年
In Vivo Instability of Reduction-mediated 99mTc-labeled Monoclonal Antibody.

Nucl. Med. Biol. 20, 617-623 1993年
放射性ヨウ素標識抗体による癌の内部照射療法を目的とする新規間接標識試薬の合成と基礎的検討(共著)

免疫核医学 8(2) 46-50 1993年
抗体の金属ラジオアイソトープ標識試薬を評価するための新しい生物学的方法(共著)

免疫核医学 8(1) 15-18 1993年
Stabilization of Ester Bond in Plasma to Enhance Target Radioactivity Delivery by Antibody Conjugated with Metallic Radionuclides through Metabolizable Ester Linkage.

J. Labelled Compds. Radiopharm. 32, 391-392 1993年
In Vivo Instability of Reduction-mediated 99mTc-labeled Monoclonal Antibody.

Nucl. Med. Biol. 20, 617-623 1993年
Cu-62 Labeled Bifunctional Radiopharmaceuticals with Metabolizable Ester Group.

Nucl. Med. Biol. 19, 33-38 1992年
Cu-62 Labeled Bifunctional Radiopharmaceuticals with Metabolizable Ester Group.

Nucl. Med. Biol. 19, 33-38 1992年
Characterization of Technetium-99m Complexes of Pentane-2,4-dione bis(N-methylthiosemicarbazone).

Chem. Pharm. Bull. 39, 104-107 1991年
Search for Radiolabeled Antibodies with High Target to Nontarget Ratio.

J. Labelled Compds. Radiopharm. 30, 104-107 1991年
A Novel Bifunctional Metabolizable Linker for the Conjugation of Antibody with Radionuclides.

Bioconjugate Chem. 2, 71-76 1991年
Characterization of Technetium-99m Complexes of Pentane-2,4-dione bis(N-methylthiosemicarbazone).

Chem. Pharm. Bull. 39, 104-107 1991年
Search for Radiolabeled Antibodies with High Target to Nontarget Ratio.

J. Labelled Compds. Radiopharm. 30, 104-107 1991年
A Novel Bifunctional Metabolizable Linker for the Conjugation of Antibody with Radionuclides.

Bioconjugate Chem. 2, 71-76 1991年
Ligandin Binding Phthalein Complexone Complex of Technetium for Hepatic Function Studies.

Eur. J. Nucl. Med. 16, 137-142 1990年
62-Cu-Labeling of Human Serum Albumin-Dithiosemicarbazone (HSA-DTS) Conjugate for Regional Plasma Volume Measurement: Application of New 62-Zn/62-Cu Generator System.

Chem. Pharm. Bull. 38, 1946-1948 1990年
Stable and Lipophilic Technetium-99m Dithiosemicarbazone Complexes with 5-6-5 membered Chelate Ring Structure.

Chem. Pharm. Bull. 38, 3099-3101 1990年
Ligandin Binding Phthalein Complexone Complex of Technetium for Hepatic Function Studies.

Eur. J. Nucl. Med. 16, 137-142 1990年
62-Cu-Labeling of Human Serum Albumin-Dithiosemicarbazone (HSA-DTS) Conjugate for Regional Plasma Volume Measurement: Application of New 62-Zn/62-Cu Generator System.

Chem. Pharm. Bull. 38, 1946-1948 1990年
Stable and Lipophilic Technetium-99m Dithiosemicarbazone Complexes with 5-6-5 membered Chelate Ring Structure.

Chem. Pharm. Bull. 38, 3099-3101 1990年
Design, Synthesis, and 64-Cu Labeling of Fatty Acid Analogs Containing Dithiosemicarbazone Chelate.

Appl. Radiat. Isot. 40, 745-749 1989年
Design, Synthesis, and 64-Cu Labeling of Fatty Acid Analogs Containing Dithiosemicarbazone Chelate.

Appl. Radiat. Isot. 40, 745-749 1989年
67-Ga-Labeled Antibodies for Immunoscintigraphy and Evaluation of Tumor Targeting of Drug-Antibody Conjugates in Mice.

Cancer Res. 48, 1189-1194 1988年
Immunoscintigraphy and Pharmacokinetics of Indium-111-Labeled Monoclonal Antibody in Patient with Malignant Melanoma.

Jpn. Cancer Res. (Gann) 79, 973-981 1988年
67-Ga-Labeled Antibodies for Immunoscintigraphy and Evaluation of Tumor Targeting of Drug-Antibody Conjugates in Mice.

Cancer Res. 48, 1189-1194 1988年
Immunoscintigraphy and Pharmacokinetics of Indium-111-Labeled Monoclonal Antibody in Patient with Malignant Melanoma.

Jpn. Cancer Res. (Gann) 79, 973-981 1988年
Procurement of Radioiodinated Glucose Derivative and Its Biological Character.

Nucl. Med. Biol. 14, 7-13 1987年
Preparation and Properties of Antitumor Monoclonal Antibodies Labeled with Metallic Radionuclides, Indium-111, Gallium-67, and Technetium-99m.

NCI Monogr. 3, 135-140 1987年
Technetium-99m-Labeled Monoclonal Antibody with Preserved Immunoreactivity and High In vivo Stability.

J. Nucl. Med. 28, 1027-1033 1987年
Preparation of Ga-67 Labeled Antibodies Using Deferoxamine as a Bifunctional Chelate: An Improved Method.

J. Immunol. Methods 104, 93-102 1987年
Procurement of Radioiodinated Glucose Derivative and Its Biological Character.

Nucl. Med. Biol. 14 (1), 7-13 1987年
Preparation and Properties of Antitumor Monoclonal Antibodies Labeled with Metallic Radionuclides, Indium-111, Gallium-67, and Technetium-99m.

NCI Monogr. 3, 135-140 1987年
Technetium-99m-Labeled Monoclonal Antibody with Preserved Immunoreactivity and High In vivo Stability.

J. Nucl. Med. 28, 1027-1033 1987年
Preparation of Ga-67 Labeled Antibodies Using Deferoxamine as a Bifunctional Chelate: An Improved Method.

J. Immunol. Methods 104, 93-102 1987年
Search for Tc-99m Labeled DTS Bifunctional Radiopharmaceutical: Role of Functional Groups in Myocardial Accumulation.

Appl. Radiat. Isot. 37, 505-511 1986年
In the Procurement of Stable Tc-99m Labeled Protein Using Bifunctional Chelating Agent.

Appl. Radiat. Isot. 37, 587-592 1986年
Design of Bifunctional Radiopharmaceutical for the Development of Tc-99m Complex for Myocardial Imaging Agents.

Nucl. Med. Biol. 13, 603-609 1986年
Search for Tc-99m Labeled DTS Bifunctional Radiopharmaceutical: Role of Functional Groups in Myocardial Accumulation.

Appl. Radiat. Isot. 37, 505-511 1986年
In the Procurement of Stable Tc-99m Labeled Protein Using Bifunctional Chelating Agent.

Appl. Radiat. Isot. 37, 587-592 1986年
Design of Bifunctional Radiopharmaceutical for the Development of Tc-99m Complex for Myocardial Imaging Agents.

Nucl. Med. Biol. 13, 603-609 1986年
｀６２´Ｃｕジチオセミカルバゾンキレートを母体にする中性ならびに二官能性放射性医薬品の開発｀６４´Ｃｕを用いる基礎的検討:―⁶⁴Cuを用いる基礎的検討―

横山陽, 細谷健夫, 荒野泰, 堀内和子

RADIOISOTOPES 35, 249-255(5) 249-255 1986年

ジェネレータから得られる⁶²Cuポジトロン金属核種の核医学への利用を考え, その基礎研究としてジチオセミカルパゾン (DTS) 誘導体のCuキレートのin vitro, in vivoにおける性質を非放射性Cuおよび⁶⁴Cuを用いて調べた。Invitro分析の結果, Cu²⁺はDTSキレート形成基と非常に速い反応速度で, コンパクト, 安定な中性単核キレートを形成することを認めた。また, マウス体内分布の検討の結果, ⁶⁴Cu-KTSでは中性キレートの性質が, また⁶⁴Cu-p-TPA-DTSではさらにbifunctional radiopharmaceuticalの性質が強く反映された。これらの結果は, 将来⁶²Cu-DTSキレートの放射性医薬品への利用の可能性を強く示唆するものである。
[125-I] Radioiodinated Metaraminol: A New Platelet-Specific Labeling Agent.

Eur. J. Nucl. Med. 10, 269-275 1985年
Synthesis and Evaluation of a New Bifunctional Chelating Agent for Tc-99m Labeling Proteins: p-Carboxyethylphenylglyoxal-di(N-methylthiosemicarbazone).

Int. J. Nucl. Med. Biol. 12, 425-430 1985年
In the Procurement of a Neutral and Compact Monomeric Complex of Dithiosemicarbazone (DTS) Derivative: Tc-99m-KTS.

Int. J. Nucl. Med. Biol. 12, 431-437 1985年
[125-I] Radioiodinated Metaraminol: A New Platelet-Specific Labeling Agent.

Eur. J. Nucl. Med. 10, 269-275 1985年
Synthesis and Evaluation of a New Bifunctional Chelating Agent for Tc-99m Labeling Proteins: p-Carboxyethylphenylglyoxal-di(N-methylthiosemicarbazone).

Int. J. Nucl. Med. Biol. 12, 425-430 1985年
In the Procurement of a Neutral and Compact Monomeric Complex of Dithiosemicarbazone (DTS) Derivative: Tc-99m-KTS.

Int. J. Nucl. Med. Biol. 12, 431-437 1985年
Tumor Imaging by Monoclonal Antibodies Labeled with Radioactive Metal Ions.

Korean J. Nucl. Med. 18, 155-163 1984年

書籍等出版物

Conjugation Chemistries to Reduce Renal Radioactivity Levels of Antibody Fragments.

Biomedical Polymers and Polymer Therapeutics (E. Chiellini, J. Sunamoto, C. Migliaresi, R. M. Ottenbrite, D. Cohn Eds.) Kluwer Academic/Plenum Publishers, New York, U.S.A. 2001年
Conjugation Chemistries to Reduce Renal Radioactivity Levels of Antibody Fragments.

Biomedical Polymers and Polymer Therapeutics (E. Chiellini, J. Sunamoto, C. Migliaresi, R. M. Ottenbrite, D. Cohn Eds.) Kluwer Academic/Plenum Publishers, New York, U.S.A. 2001年
Intracellular Metabolism of 99mTc-Labeled Polypeptides using Hydrazino Nicotinamide (HYNIC) as a Chelating Agent.

Technetium in Chemistry and Nuclear Medicine (Nicolini M.and Mazzi U. eds.) Edizion Minerva Medica, Corso Bramante, Italy, 1999年
Intracellular Metabolism of 99mTc-Labeled Polypeptides using Hydrazino Nicotinamide (HYNIC) as a Chelating Agent.

Technetium in Chemistry and Nuclear Medicine (Nicolini M.and Mazzi U. eds.) Edizion Minerva Medica, Corso Bramante, Italy 1999年
A Chemical Strategy to Reduce Renal Radioactivity Levels of Antibody Fragments.

Synthesis and Applications of Isotopically Labelled Compounds 1997. R.L. Heys and D.G. Melillo eds. John Wiley & Sons, Chichester, UK. 1998年