矢貝 史樹

By controlling the π-π stacking of chlorophyll supramolecular rosettes through steric hindrance of alkyl dendrons, it become possible to create chlorophyll tubes and discrete rings that resemble to natural chlorophyll assemblies.

Hydrogen-bonded supermacrocycles (rosettes) composed of dinaphthylethene π-conjugated systems show unique supramolecular polymorphism affording nanorings and nanorods via kinetically controlled self-assembly.

Insolubility of functional molecules caused by polymorphism sometimes poses limitations for their solution‐based processing. Such a situation can also occur in the preparation processes of supramolecular polymers formed in a solution. An effective strategy to address this issue is to prepare amorphous solid states by introducing a “coformer” molecule capable of inhibiting the formation of an insoluble polymorph through co‐aggregation. Herein, inspired by the coformer approach, we demonstrated a solubility enhancement of a barbiturate π‐conjugated compound that can supramolecularly polymerize through six‐membered hydrogen‐bonded rosettes. Our newly synthesized supramolecular coformer molecule features a sterically demanding methyl group in the π‐conjugated unit of the parent molecule. Although the parent molecule exhibits low solubility in nonpolar solvents due to the formation of a crystalline polymorph comprising a tape‐like hydrogen‐bonded array prior to the supramolecular polymerization, mixing with the coformer compound enhanced the solubility by inhibiting mesoscopic organization of the tapes. The two monomers were then co‐polymerized into desired helicoidal supramolecular polymers through the formation of heteromeric rosettes.

Toroidal and helicoidal supramolecular polymers allow us to observe distinct kinetics of secondary nucleation on the aggregate surface and elongation from the facet of aggregate termini on seeded supramolecular polymerization.

The reduction in the inner diameter of the nanotoroids of a π-conjugated barbiturate monomer results in nano-[2]catenanes in a high yield due to enhanced secondary nucleation and subsequent steric suppression of further catenation.

Self-assembly pathways of barbituric acid dyes can be dramatically changed by partial O-to-S substitution for a critical CO group of the hydrogen-bonding barbituric acid group.

Introduction of the bulky yet strongly aggregating cholesterol units to an azobenzene dyad lead to a supramolecular polymorphism not only in its temperature-controlled but also in photo-triggered self-assembly, leading to toroids and helical fibers.

Two barbiturate dyes with regioisomeric thiophene-cored twisted π-systems show strongly enhanced emission through supramolecular polymerization. The supramolecular polymers thus formed exhibit distinct emission colors and degree of agglomeration.

Synthesis of one-dimensional nanofibers with distinct topological (higher-order structural) domains in the same main chain is one of the challenging topics in modern supramolecular polymer chemistry. Non-uniform structural transformation of supramolecular polymer chains by external stimuli may enable preparation of such nanofibers. To demonstrate feasibility of this post-polymerization strategy, we prepared a photoresponsive helically folded supramolecular polymers from a barbiturate monomer containing an azobenzene-embedded rigid π-conjugated scaffold. In contrast to previous helically folded supramolecular polymers composed of a more flexible azobenzene monomer, UV-light induced unfolding of the newly prepared helically folded supramolecular polymers occurred nonuniformly, affording topological block copolymers consisting of folded and unfolded domains. The formation of such blocky copolymers indicates that the photoinduced unfolding of the helically folded structures initiates from relatively flexible parts such as termini or defects. Spontaneous refolding of the unfolded domains was observed after visible-light irradiation followed by aging to restore fully folded structures.

Helical folding of randomly coiled linear polymers is an essential organization process not only for biological polypeptides but also for synthetic functional polymers. Realization of this dynamic process in supramolecular polymers (SPs) is, however, a formidable challenge because of their inherent lability of main chains upon changing an external environment that can drive the folding process (e.g., solvent, concentration, and temperature). We herein report a photoinduced reversible folding/unfolding of rosette-based SPs driven by photoisomerization of a diarylethene (DAE). Temperature-controlled supramolecular polymerization of a barbiturate-functionalized DAE (open isomer) in nonpolar solvent results in the formation of intrinsically curved, but randomly coiled, SPs due to the presence of defects. Irradiation of the randomly coiled SPs with UV light causes efficient ring-closure reaction of the DAE moieties, which induces helical folding of the randomly coiled structures into helicoidal ones, as evidenced by atomic force microscopy and small-angle X-ray scattering. The helical folding is driven by internal structure ordering of the SP fiber that repairs the defects and interloop interaction occurring only for the resulting helicoidal structure. In contrast, direct supramolecular polymerization of the ring-closed DAE monomers by temperature control affords linearly extended ribbon-like SPs lacking intrinsic curvature that are thermodynamically less stable compared to the helicoidal SPs. The finding represents an important concept applicable to other SP systems; that is, postpolymerization (photo)reaction of preorganized kinetic structures can lead to more thermodynamically stable structures that are inaccessible directly through temperature-controlled protocols.

<p>A novel barbiturate-functionalized supramolecular monomer provides unprecedented wavy supramolecular polymers with periodic inversion of curvature domains <italic>via</italic> the formation of hydrogen-bonded rosettes.</p>

Molecular recognition to preorganize noncovalently polymerizable supramolecular complexes is a characteristic process of natural supramolecular polymers, and such recognition processes allow for dynamic self-alteration, yielding complex polymer systems with extraordinarily high efficiency in their targeted function. We herein show an example of such molecular recognition-controlled kinetic assembly/disassembly processes within artificial supramolecular polymer systems using six-membered hydrogen-bonded supramolecular complexes (rosettes). Electron-rich and poor monomers are prepared that kinetically coassemble through a temperature-controlled protocol into amorphous coaggregates comprising a diverse mixture of rosettes. Over days, the electrostatic interaction between two monomers induces an integrative self-sorting of rosettes. While the electron-rich monomer inherently forms toroidal homopolymers, the additional electrostatic interaction that can also guide rosette association allows helicoidal growth of supramolecular copolymers that are comprised of an alternating array of two monomers. Upon heating, the helicoidal copolymers undergo a catastrophic transition into amorphous coaggregates via entropy-driven randomization of the monomers in the rosette.

An ester-containing a barbiturated p-conjugated molecule exhibits a kinetic supramolecular polymorph with outstanding morphological and fluorescent changes. Metastable supramolecular polymers with an orange emission spontaneously transform into thermodynamically stable crystalline phase exhibiting a green emission.

Solvents have a significant effect on the thermodynamic properties of supramolecular polymers. In this study we investigated self-assembly of a barbiturated naphthalene molecule that affords toroidal supramolecular polymers in cyclic and acyclic alkanes. Although the toroidal structures were observed in all the solvents, their thermodynamic parameters were largely different between cyclic and acyclic alkanes due to different dielectric constants.

© 2019 American Chemical Society. We developed the diversity-oriented approach for the synthesis of tetrathia[8]circulenes with a variety of peripheral substituents. Iridium-catalyzed direct C-H borylation of tetrathienylene provided 1,4,7,10-tetraboryltetrathienylene as a major product. 1,4,7,10-Tetraboryltetrathienylene served as an a key intermediate to achieve the selective synthesis of octasubstituted or tetrasubstituted tetrathia[8]circulenes via rhodium-catalyzed annulation with symmetric internal alkynes or sequential Sonogashira-Hagihara coupling and base-promoted intramolecular cyclization. A variety of substituents were installed at the peripheral positions of tetrathia[8]circulenes systematically. The self-assembling behavior of tetrathia[8]circulenes was investigated using 1H NMR and AFM measurements. The number and the chain length of alkyl groups exerted a significant influence on the aggregation ability and the crystal packing structures of tetrathia[8]circulenes in both solution and solid states. We also found that the molecular arrangement of the self-assembled tetrathia[8]circulene molecules affected the hole mobility assessed by the FP-TRMC method.

<p>Two scissor-shaped azobenzene dyads bearing either linear alkyl or perfluoroalkyl side chains undergo distinct assembly pathways.</p>

<p>Inversion of the amide connectivity of an azobenzene dyad, which self-assembles into chiral toroids and nanotubes, improves the thermal stability of the assemblies, however it negatively affects supramolecular chirality.</p>

<p>Transformation of metastable supramolecular stacks of hydrogen-bonded rosettes composed of an ester-containing barbiturated naphthalene into crystalline nanosheets occurs through the rearrangement of hydrogen-bonding patterns.</p>

Supramolecular polymers have emerged in the last decade as highly accessible polymeric nanomaterials. An important step toward finely designed nanomaterials with versatile functions, such as those of natural proteins, is intricate topological control over their main chains. Herein, we report the facile one-shot preparation of supramolecular copolymers involving segregated secondary structures. By cooling non-polar solutions containing two monomers that individually afford helically folded and linearly extended secondary structures, we obtain unique nanofibers with coexisting distinct secondary structures. A spectroscopic analysis of the formation process of such topologically chimeric fibers reveals that the monomer composition varies gradually during the polymerization due to the formation of heteromeric hydrogen-bonded intermediates. We further demonstrate the folding of these chimeric fibers by light-induced deformation of the linearly extended segments.

Kinetically formed metastable molecular assemblies have attracted increasing interest especially in the field of supramolecular polymers. In most cases, metastable assemblies are ensemblies of aggregates based on the same supramolecular motif but with different lengths or sizes, and therefore their kinetic stabilities are experimentally indistinguishable. Herein, we demonstrate a topological effect on kinetic stabilities in a complex mixture of metastable supramolecular polymers. Our azobenzene-incorporated monomer upon heating in nonpolar solvent at ambient temperature kinetically forms complex mixtures of supramolecular polymers with cyclized and open-ended randomly coiled topologies. Upon further heating, we obtained thermodynamically stable twisted fibrils organizing into crystalline fibers. Through the direct visualization of the complex supramolecular polymer mixtures by atomic force microscopy, we demonstrate that the cyclized supramolecular polymer has superior kinetic stability compared to the open-ended species toward the thermal transformation into twisted fibrils. Since the superior kinetic stability of the cyclized species can be attributed to the absence of aggregate termini, we could convert them fully into the thermodynamic species through photoinduced opening of the cyclized structures.