関直彦

研究者氏名	関直彦
	セキナオヒコ
通称等の別名	千葉大学大学院医学研究院機能ゲノム学
URL
所属	千葉大学
部署	大学院医学研究院
職名	准教授
学位	医学博士(千葉大学)
科研費研究者番号	50345013
J-Global ID	200901004712087610

プロフィール

1991年千葉大学大学院医学研究科博士課程修了（医学博士）
1991年科学技術庁放射線医学総合研究所客員研究官
1992年かずさDNA研究所遺伝子構造第１研究室研究員
1999年ヘリックス研究所第３研究部門主任研究員
2002年千葉大学大学院医学研究院研究准教授
2015年千葉大学大学院医学研究院准教授

研究キーワード

腫瘍学 ,マイクロRNA ,機能性RNA ,ゲノム医学

研究分野

ライフサイエンス / 腫瘍生物学 /

論文

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Synthetic Circular RNA for microRNA-1269a Suppresses Tumor Progression in Oral Squamous Cell Carcinoma

Atsushi Kasamatsu Ryunosuke Nozaki Kohei Kawasaki Tomoaki Saito Chikashi Minemura Naohiko Seki Joel Moss Katsuhiro Uzawa

Cancers 16(6) 1242-1242 2024年3月

microRNAs (miRs) function in cancer progression as post-transcriptional regulators. We previously reported that endogenous circular RNAs (circRNAs) function as efficient miR sponges and could act as novel gene regulators in oral squamous cell carc...

Identification of MicroRNAs Associated with Histological Grade in Early-Stage Invasive Breast Cancer.

Sasagu Kurozumi Naohiko Seki Eriko Narusawa Chikako Honda Shoko Tokuda Yuko Nakazawa Takehiko Yokobori Ayaka Katayama Nigel P Mongan Emad A Rakha Tetsunari Oyama Takaaki Fujii Ken Shirabe Jun Horiguchi

International journal of molecular sciences 25(1) 2023年12月 [査読有り]

This study aimed to identify microRNAs associated with histological grade using comprehensive microRNA analysis data obtained by next-generation sequencing from early-stage invasive breast cancer. RNA-seq data from normal breast and breast cancer ...

Identification of Tumor-Suppressive miR-139-3p-Regulated Genes: TRIP13 as a Therapeutic Target in Lung Adenocarcinoma.

Yoko Hagihara Yuya Tomioka Takayuki Suetsugu Masahiro Shinmura Shunsuke Misono Yusuke Goto Naoko Kikkawa Mayuko Kato Hiromasa Inoue Keiko Mizuno Naohiko Seki

Cancers 15(23) 2023年11月 [査読有り]

Analyses of our microRNA (miRNA) expression signature combined with The Cancer Genome Atlas (TCGA) data revealed that both strands of pre-miR-139 (miR-139-5p, the guide strand, and miR-139-3p, the passenger strand) are significantly downregulated ...

Oncogenic Targets Regulated by Tumor-Suppressive miR-30c-1-3p and miR-30c-2-3p: TRIP13 Facilitates Cancer Cell Aggressiveness in Breast Cancer.

Reiko Mitsueda Hiroko Toda Yoshiaki Shinden Kosuke Fukuda Ryutaro Yasudome Mayuko Kato Naoko Kikkawa Takao Ohtsuka Akihiro Nakajo Naohiko Seki

Cancers 15(16) 2023年8月 [査読有り]

Accumulating evidence suggests that the miR-30 family act as critical players (tumor-suppressor or oncogenic) in a wide range of human cancers. Analysis of microRNA (miRNA) expression signatures and The Cancer Genome Atlas (TCGA) database revealed...

Minichromosome maintenance proteins in lung adenocarcinoma: Clinical significance and therapeutic targets.

Kengo Tanigawa Yuya Tomioka Shunsuke Misono Shunichi Asai Naoko Kikkawa Yoko Hagihara Takayuki Suetsugu Hiromasa Inoue Keiko Mizuno Naohiko Seki

FEBS open bio 2023年7月 [査読有り]

Lung cancer is the most common cause of cancer-related death worldwide, accounting for 1.8 million deaths annually. Analysis of The Cancer Genome Atlas data showed that all members of the minichromosome maintenance (MCM) family (hexamers involved ...