Jin Kumagai Masahiro Kiuchi Kota Kokubo Hiroyuki Yagyu Masahiro Nemoto Kaori Tsuji Ken Nagahata Atsushi Sasaki Takahisa Hishiya Miki Onoue Rie Shinmi Yuri Sonobe Tomohisa Iinuma Syuji Yonekura Jun Shinga Toyoyuki Hanazawa Haruhiko Koseki Toshinori Nakayama Koutaro Yokote Kiyoshi Hirahara
Proceedings of the National Academy of Sciences of the United States of America 120(49) e2302903120 2023年9月 [査読有り]
Uncontrolled type 2 immunity by type 2 helper T (Th2) cells causes intractable allergic diseases; however, whether the interaction of CD4+ T cells shapes the pathophysiology of allergic diseases remains unclear. We identified a subset of Th2 cells...
Proceedings of the National Academy of Sciences of the United States of America 120(2) e2218345120 2023年1月 [査読有り]
CD4+ memory T cells are central to long-lasting protective immunity and are involved in shaping the pathophysiology of chronic inflammation. While metabolic reprogramming is critical for the generation of memory T cells, the mechanisms controlling...
Allergic conjunctivitis is a chronic inflammatory disease that is characterized by severe itch in the conjunctiva, but how neuro-immune interactions shape the pathogenesis of severe itch remains unclear. We identified a subset of memory-type patho...
The Journal of allergy and clinical immunology 2022年7月 [査読有り]
BACKGROUND: Allergic rhinitis is a growing problem worldwide. Currently, the only treatment that can modify the disease is antigen-specific immunotherapy; however, its mechanism(s) of action is not fully understood. OBJECTIVE: To comprehensively i...
大学院国際学術研究院