Akinori Takemura Sanae Ishii Yugo Ikeyama Katsuhiro Esashika Jun Takahashi Kousei Ito
Drug metabolism and pharmacokinetics 52 100511 2023年4月 [査読有り]
Drug-induced liver injury (DILI) is a major factor underlying drug withdrawal from the market. Therefore, it is important to predict DILI during the early phase of drug discovery. Metabolic activation and mitochondrial toxicity are good indicators...
Ryota Nakajima Akinori Takemura Yugo Ikeyama Kousei Ito
The Journal of toxicological sciences 48(2) 65-73 2023年2月 [査読有り]
Lipopolysaccharide (LPS), a component of the outer membrane of gram-negative bacteria, induces various biological reactions in vivo. Our previous study suggested that LPS administration disrupts respiratory chain complex activities, enhances react...
Takumi Nukaga Akinori Takemura Yuka Endo Yoshihiro Uesawa Kousei Ito
Toxicology Research 2023年1月 [査読有り]
Drug-induced liver injury (DILI) is a major factor influencing new drug withdrawal; therefore, an appropriate toxicity assessment at the preclinical stage is required. Previous in silico models have been established using compound information list...
Methods in molecular biology (Clifton, N.J.) 2544 119-127 2022年 [査読有り][招待有り]
Inhibition of bile acid excretion by drugs is a significant factor in the development of drug-induced cholestatic liver injury. We constructed a new in vitro assay system to detect bile acid-dependent cytotoxicity in hepatocytes. This cell-based s...
Chika Yamamoto Akinori Takemura Sanae Ishii Atsushi Doi Isao Saito Hideki Yamada Yoko Sakai Tamihide Matsunaga Kousei Ito
The Journal of toxicological sciences 47(1) 13-18 2022年 [査読有り]
The liver microphysiological system (MPS) model is an in-vitro culture method that mimics physiological blood flow, which enhances basal cellular functions. However, the liver MPS model has not been tested in the preclinical stage because of its o...
大学院国際学術研究院