藤橋浩太郎

研究者氏名	藤橋浩太郎
	フジハシコウタロウ
URL
所属	千葉大学
部署	医学部附属病院ヒト粘膜ワクチン学部門
職名	特任教授
学位	博士（歯学）(大阪大学)
その他の所属	東京大学医科学研究所, アラバマ大学バーミングハム校歯学部　小児歯科学講座
J-Global ID	201801016607667154

研究キーワード

感染症 ,老化 ,粘膜ワクチン ,粘膜免疫

研究分野

ライフサイエンス / 免疫学 / 粘膜免疫

経歴

2022年4月

現在

千葉大学千葉大学医学部附属病院ヒト粘膜ワクチン学部門特任教授

委員歴

2015年1月

2020年12月

American Association of Immunologists Program Chair: Vaccines and Immunotherapy

論文

12 3 4 5 >

MucoRice-CTB line 19A, a new marker-free transgenic rice-based cholera vaccine produced in an LED-based hydroponic system

Yoshikazu Yuki Shiho Kurokawa Kotomi Sugiura Koji Kashima Shinichi Maruyama Tomoyuki Yamanoue Ayaka Honma Mio Mejima Natsumi Takeyama Masaharu Kuroda Hiroko Kozuka-Hata Masaaki Oyama Takehiro Masumura Rika Nakahashi-Ouchida Kohtaro Fujihashi Takashi Hiraizumi Eiji Goto Hiroshi Kiyono

Frontiers in Plant Science 15 2024年3月

We previously established the selection-marker-free rice-based oral cholera vaccine (MucoRice-CTB) line 51A for human use by Agrobacterium-mediated co-transformation and conducted a double-blind, randomized, placebo-controlled phase I trial in Jap...

Cationic-nanogel nasal vaccine containing the ectodomain of RSV-small hydrophobic protein induces protective immunity in rodents.

Shingo Umemoto Rika Nakahashi-Ouchida Yoshikazu Yuki Shiho Kurokawa Tomonori Machita Yohei Uchida Hiromi Mori Tomoyuki Yamanoue Takehiko Shibata Shin-Ichi Sawada Kazuya Ishige Takashi Hirano Kohtaro Fujihashi Kazunari Akiyoshi Yosuke Kurashima Daisuke Tokuhara Peter B Ernst Masashi Suzuki Hiroshi Kiyono

NPJ vaccines 8(1) 106-106 2023年7月

Respiratory syncytial virus (RSV) is a leading cause of upper and lower respiratory tract infection, especially in children and the elderly. Various vaccines containing the major transmembrane surface proteins of RSV (proteins F and G) have been t...

Human salivary protein-derived peptides specific-salivary SIgA antibodies enhanced by nasal double DNA adjuvant in mice play an essential role in preventing Porphyromonas gingivalis colonization: an in-vitro study

Kayo Koyanagi Kosuke Kataoka Hideki Yoshimatsu Kohtaro Fujihashi Tatsuro Miyake

BMC Oral Health 2023年2月

Nasal vaccines: solutions for respiratory infectious diseases.

Rika Nakahashi-Ouchida Kohtaro Fujihashi Yosuke Kurashima Yoshikazu Yuki Hiroshi Kiyono

Trends in molecular medicine 29(2) 124-140 2022年11月

Nasal vaccines induce pathogen-specific dual protective immunity at mucosal surfaces and systemically throughout the body. Consequently, nasal vaccines both prevent pathogen invasion and reduce disease severity. Because of these features, nasal va...

Oral MucoRice-CTB vaccine is safe and immunogenic in healthy US adults.

Yoshikazu Yuki Masanori Nojima Koji Kashima Kotomi Sugiura Shinichi Maruyama Shiho Kurokawa Tomoyuki Yamanoue Rika Nakahashi-Ouchida Hiroyuki Nakajima Takashi Hiraizumi Hitoshi Kohno Eiji Goto Kohtaro Fujihashi Hiroshi Kiyono

Vaccine 2022年4月 [査読有り]

MucoRice-CTB is a promising cold-chain-free oral cholera vaccine candidate. Here, we report a double-blind, randomized, placebo-controlled, phase I study conducted in the USA in which vaccination with the 6-g dose of MucoRice-CTB induced cross-rea...