To meet the energetic requirements associated with activation, proliferation and survival, T cells switch their metabolic signatures from energetically quiescent to activated. However, little is known about the role of metabolic pathway controllin...
Ryo Koyama-Nasu   Motoko Y Kimura   Masahiro Kiuchi   Ami Aoki   Yangsong Wang   Yukiyoshi Mita   Ichita Hasegawa   Yukihiro Endo   Atsushi Onodera   Kiyoshi Hirahara   Shinichiro Motohashi   Toshinori Nakayama   
Cancer immunology research 2023年5月 [査読有り]
Tumor-specific CD8+ T cells play a pivotal role in anti-tumor immunity and are a key target of immunotherapeutic approaches. Intratumoral CD8+ T cells are heterogeneous; Tcf1+ stem-like CD8+ T cells give rise to their cytotoxic progeny - Tim-3+ te...
Proceedings of the National Academy of Sciences of the United States of America 119(33) e2203437119 2022年8月 [査読有り]
The mortality of coronavirus disease 2019 (COVID-19) is strongly correlated with pulmonary vascular pathology accompanied by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection-triggered immune dysregulation and aberrant activat...
Journal of Clinical Medicine 11(14) 2022年7月 [査読有り]
Regarding vascularized lymph node transfer (VLNT) for lymphedema, partial blood flow impairment in transferred lymph node (LN) flaps may adversely affect the therapeutic results. We investigated the clinical and histological effects of partial blo...