Go Yoshimura Jukiya Sakamoto Mariko Kitajima Hayato Ishikawa
Chemistry (Weinheim an der Bergstrasse, Germany) e202401153 2024年4月
There are many indole alkaloids that contain diverse functional groups attached to the benzene ring on the indole core. Promising biological activities of these alkaloids have been reported. Herein, we report the indole C5-selective bromination of...
Sho Imaoka Yuta Nakashima Mariko Kitajima Hayato Ishikawa
Chemical & pharmaceutical bulletin 72(1) 68-74 2024年
The first enantioselective total synthesis of kopsiyunnanine B, which has a unique folded and complex pentacyclic structure containing six contiguous chiral centers, has been achieved along our originally proposed biosynthetic pathway. The key rea...
The aggregation of amyloid-β (Aβ) remains the most acceptable pathological hallmark of Alzheimer's disease (AD). In search for natural products exhibiting anti-amyloidogenic effects, phytochemical analyses were conducted on Uncaria lanosa f. phili...
The enantioselective total syntheses of (-)-silicine and (-)-20-episilicine, which contain a chiral piperidine with three contiguous chiral centers (D-ring) and a strained seven-membered ring (C-ring) attached to an indole, were achieved. The key ...
JOURNAL OF SYNTHETIC ORGANIC CHEMISTRY JAPAN 79(2) 145-154 2021年2月
For more than a century, quinine (1) has remained a persistent fascination to human beings for its use in medicine and chemistry. More recently, 1 has garnered increased attention due to its widespread application in the field of asymmetric cataly...
大学院国際学術研究院