樋坂章博

研究者氏名	樋坂章博
	ヒサカアキヒロ
URL	https://www.p.chiba-u.jp/lab/cpp/index.html
所属	千葉大学
部署	大学院薬学研究院臨床薬理学
職名	教授
J-Global ID	200901048175626060

研究キーワード

臨床薬理学 ,薬物動態学 ,Pharmacokinetics and Clinical Pharmacology

研究分野

ライフサイエンス / 医療薬学 /

学歴

北海道大学薬学部薬学科

北海道大学薬学研究科

委員歴

HAB研究機構理事

日本薬物動態学会評議員

論文

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Involvement of multiple cytochrome P450 isoenzymes in drug interactions between ritonavir and direct oral anticoagulants

Yuta Tamemoto Yukihiro Shibata Natsumi Hashimoto Hiromi Sato Akihiro Hisaka

Drug Metabolism and Pharmacokinetics 53 100498-100498 2023年12月

Model-based meta-analysis of ethnic differences and their variabilities in clearance of oral drugs classified by clearance mechanism.

Hiromi Sato Rika Marutani Ryota Takaoka Daniel Mori-Fegan Xinying Wang Kazuya Maeda Hiroyuki Kusuhara Hiroshi Suzuki Hideki Yoshioka Akihiro Hisaka

CPT: pharmacometrics & systems pharmacology 12(8) 1132-1142 2023年6月

In this study, the ethnic ratios (ERs) of oral clearance between Japanese and Western populations were subjected to model-based meta-analysis (MBMA) for 81 drugs evaluated in 673 clinical studies. The drugs were classified into eight groups accord...

Integrated Use of In Vitro and In Vivo Information for Comprehensive Prediction of Drug Interactions Due to Inhibition of Multiple CYP Isoenzymes

Shizuka Hozuki Hideki Yoshioka Satoshi Asano Mikiko Nakamura Saori Koh Yukihiro Shibata Yuta Tamemoto Hiromi Sato Akihiro Hisaka

Clinical Pharmacokinetics 62(6) 849-860 2023年4月

Tumor-associated neutrophils and macrophages exacerbate antidrug IgG-mediated anaphylactic reaction against an immune checkpoint inhibitor

Takahiro Arai Tomomi Kokubo Ruiheng Tang Hirohito Abo Ayu Terui Jotaro Hirakawa Hidetaka Akita Hiroto Kawashima Akihiro Hisaka Hiroto Hatakeyama

Journal for ImmunoTherapy of Cancer 10(12) e005657-e005657 2022年12月

Background

With the increased use of immune checkpoint inhibitors (ICIs), side effects and toxicity are a great concern. Anaphylaxis has been identified as a potential adverse event induced by ICIs. Anaphylaxis is a life-threatening medical emerg...

Delivery of aPD-L1 antibody to i.p. tumors via direct penetration by i.p. route: Beyond EPR effect

Mayu Yamamoto Taiki Kurino Reiko Matsuda Haleigh Sakura Jones Yoshito Nakamura Taisei Kanamori Atushi B. Tsuji Aya Sugyo Ryota Tsuda Yui Matsumoto Yu Sakurai Hiroyuki Suzuki Makoto Sano Kensuke Osada Tomoya Uehara Yukimoto Ishii Hidetaka Akita Yasushi Arano Akihiro Hisaka Hiroto Hatakeyama

Journal of Controlled Release 352 328-337 2022年12月 [査読有り]