Sterol regulatory element-binding proteins (SREBPs) are key transcription factors that control fatty acid and cholesterol metabolism. As the major SREBP isoform in macrophages, SREBP1a is also required for inflammatory and phagocytotic functions. ...
The liver stores glycogen and releases glucose into the blood upon increased energy demand. Group 2 innate lymphoid cells (ILC2) in adipose and pancreatic tissues are known for their involvement in glucose homeostasis, but the metabolic contributi...
Lena Sasaki Yuki Hamada Daisuke Yarimizu Tomo Suzuki Hiroki Nakamura Aya Shimada Khanh Tien Nguyen Pham Xinyan Shao Koki Yamamura Tsutomu Inatomi Hironobu Morinaga Emi K. Nishimura Fujimi Kudo Ichiro Manabe Shogo Haraguchi Yuki Sugiura Makoto Suematsu Shigeru Kinoshita Mamiko Machida Takeshi Nakajima Hiroshi Kiyonari Hitoshi Okamura Yoshiaki Yamaguchi Takahito Miyake Masao Doi
Nature Aging 2(2) 105-114 2022年2月
Abstract
Canonically, hormones are produced in the endocrine organs and delivered to target tissues. However, for steroids, the concept of tissue intracrinology, whereby hormones are produced in the tissues where they exert their effect without r...
Lin Liu Hiroyuki Koike Takehito Ono Shinichiro Hayashi Fujimi Kudo Atsushi Kaneda Hiroyuki Kagechika Ichiro Manabe Tomoki Nakashima Yumiko Oishi
Proceedings of the National Academy of Sciences 118(35) e2102895118-e2102895118 2021年8月
Skeletal muscle atrophy is caused by various conditions, including aging, disuse related to a sedentary lifestyle and lack of physical activity, and cachexia. Our insufficient understanding of the molecular mechanism underlying muscle atrophy limi...
International immunology 34(2) 81-95 2021年6月 [査読有り]
The heart is highly innervated by autonomic neurons, and dynamic autonomic regulation of the heart and blood vessels is essential for animals to carry out the normal activities of life. Cardiovascular diseases, including heart failure and myocardi...
大学院国際学術研究院