Auto-antibodies (auto-abs) to type I interferons (IFNs) have been identified in patients with life-threatening coronavirus disease 2019 (COVID-19), suggesting that the presence of auto-abs may be a risk factor for disease seve...
Chiaki Iwamura Hidetaka Ohnuki Francis A Flomerfelt Lixin Zheng Alexie Carletti Hidefumi Wakashin Yohei Mikami Stephen R Brooks Yuka Kanno Ronald E Gress Giovanna Tosato Toshinori Nakayama John J O'Shea Alan Sher Dragana Jankovic
Nature immunology 2023年11月
Aberrant differentiation of progenitor cells in the hematopoietic system is known to severely impact host immune responsiveness. Here we demonstrate that NOD1, a cytosolic innate sensor of bacterial peptidoglycan, also functions in murine hematopo...
Proceedings of the National Academy of Sciences of the United States of America 120(2) e2218345120 2023年1月 [査読有り]
CD4+ memory T cells are central to long-lasting protective immunity and are involved in shaping the pathophysiology of chronic inflammation. While metabolic reprogramming is critical for the generation of memory T cells, the mechanisms controlling...
大学院国際学術研究院