BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 321(3) 728-735 2004年8月
Aggregated LDL (AgLDL) accumulates within the subendothelial space of developing atherosclerotic lesions. We were interested to learn whether endothelial cells can interact with AgLDL. Incubation of endothelial cells with AgLDL resulted in apparen...
CYP3A4 exhibits unusual kinetic characteristics that result from the metabolism of multiple substrate including endogenous steroids and some drugs that coexist at the active site. To clarify the mechanism of the effect of endogenous steroids on th...
N Torimoto Ishii, I M Hata H Nakamura H Imada N Ariyoshi S Ohmori T Igarashi M Kitada
BIOCHEMISTRY 42(51) 15068-15077 2003年12月
CYP3A4 exhibits unusual kinetic characteristics that result from the metabolism of multiple substrate including endogenous steroids and some drugs that coexist at the active site. To clarify the mechanism of the effect of endogenous steroids on th...
Drug Metabolism and Disposition 31(4) 432-438 2003年4月
Recently, we reported that several endogenous steroids affect CYP3A4-mediated drug metabolism, using human adult liver microsomes as an enzyme source. Especially, carbamazepine (CBZ) 10,11-epoxidation is activated by androstenedione (AND). In the ...
Drug Metabolism and Disposition 31(4) 432-438 2003年4月
Recently, we reported that several endogenous steroids affect CYP3A4-mediated drug metabolism, using human adult liver microsomes as an enzyme source. Especially, carbamazepine (CBZ) 10,11-epoxidation is activated by androstenedione (AND). In the ...
大学院国際学術研究院