Auto-antibodies (auto-abs) to type I interferons (IFNs) have been identified in patients with life-threatening coronavirus disease 2019 (COVID-19), suggesting that the presence of auto-abs may be a risk factor for disease seve...
Minako Koura Yosuke Kameoka Fukuko Kishi Yoshio Yamakawa Fuyu Ito Ryuichi Sugamata Yuko Doi Kazuko Uno Toshinori Nakayama Takashi Miki Hiroshi Nakajima Kazuo Suzuki Osamu Suzuki
Clinical and experimental immunology 2023年12月
Based on the efficacy of intravenous immunoglobulin (IVIg) for the treatment of antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV), we developed a recombinant single-chain-fragment variable clone, VasSF, therapeutic against AAV...
Jin Kumagai Masahiro Kiuchi Kota Kokubo Hiroyuki Yagyu Masahiro Nemoto Kaori Tsuji Ken Nagahata Atsushi Sasaki Takahisa Hishiya Miki Onoue Rie Shinmi Yuri Sonobe Tomohisa Iinuma Syuji Yonekura Jun Shinga Toyoyuki Hanazawa Haruhiko Koseki Toshinori Nakayama Koutaro Yokote Kiyoshi Hirahara
Proceedings of the National Academy of Sciences of the United States of America 120(49) e2302903120 2023年12月
Uncontrolled type 2 immunity by type 2 helper T (Th2) cells causes intractable allergic diseases; however, whether the interaction of CD4+ T cells shapes the pathophysiology of allergic diseases remains unclear. We identified a subset of Th2 cells...
To meet the energetic requirements associated with activation, proliferation and survival, T cells switch their metabolic signatures from energetically quiescent to activated. However, little is known about the role of metabolic pathway controllin...
大学院国際学術研究院