Go Yoshimura Jukiya Sakamoto Mariko Kitajima Hayato Ishikawa
Chemistry (Weinheim an der Bergstrasse, Germany) e202401153 2024年4月
There are many indole alkaloids that contain diverse functional groups attached to the benzene ring on the indole core. Promising biological activities of these alkaloids have been reported. Herein, we report the indole C5-selective bromination of...
Sho Imaoka Yuta Nakashima Mariko Kitajima Hayato Ishikawa
Chemical & pharmaceutical bulletin 72(1) 68-74 2024年
The first enantioselective total synthesis of kopsiyunnanine B, which has a unique folded and complex pentacyclic structure containing six contiguous chiral centers, has been achieved along our originally proposed biosynthetic pathway. The key rea...
The enantioselective total syntheses of (-)-silicine and (-)-20-episilicine, which contain a chiral piperidine with three contiguous chiral centers (D-ring) and a strained seven-membered ring (C-ring) attached to an indole, were achieved. The key ...
Yuta Nakashima Taichi Inoshita Mariko Kitajima Hayato Ishikawa
Organic Letters 25(7) 1151-1155 2023年2月 [査読有り]
The first asymmetric total synthesis of the Lycopodium alkaloid senepodine F, which contains a decahydroquinoline ring (AB-ring) and a quinolizidine ring (CD-ring) connected by a methylene tether, has been achieved. The key steps of this synthesis...
大学院国際学術研究院