Beta-hydroxybutyrate (BHB), an endogenous NLRP3 inflammasome inhibitor, has been shown to be associated with the pathophysiology of depression in rodents. However its active mechanism has not been revealed. Herein, we probed both the pathways and ...
Xingming Wang Akifumi Eguchi Yong Yang Lijia Chang Xiayun Wan Jiajing Shan Youge Qu Li Ma Chisato Mori Jianjun Yang Kenji Hashimoto
Neurobiology of Disease 176 2023年1月
Multiple sclerosis (MS) is the most common demyelinating disease that attacks the central nervous system. Dietary intake of cuprizone (CPZ) produces demyelination resembling that of patients with MS. Given the role of the vagus nerve in gut–microb...
Yukihiko Shirayama Masaaki Iwata Yuko Fujita Yasunori Oda Kenji Hashimoto
Behavioural brain research 113769-113769 2022年1月
Finding from animal models of depression indicated that Toll-like receptor 4 (TLR4) is associated with the pathophysiology of depression. Herein, the TLR4 antagonists TAK-242 and baicalin induced antidepressant-like effects in a rat learned helple...
Li Ma Jiancheng Zhang Yuko Fujita Youge Qu Jiajing Shan Xiayun Wan Xingming Wang Tamaki Ishima Kenta Kobayashi Long Wang Kenji Hashimoto
Translational psychiatry 12(1) 27-27 2022年1月
(R, S)-ketamine has prophylactic antidepressant-like effects in rodents; however, the precise molecular mechanisms underlying its action remain unknown. Using RNA-sequencing analysis, we searched novel molecular target(s) that contribute to the pr...
Yaoyu Pu Jun Yang Lijia Chang Youge Qu Siming Wang Kai Zhang Zhongwei Xiong Jiancheng Zhang Yunfei Tan Xingming Wang Yuko Fujita Tamaki Ishima Debin Wan Sung Hee Hwang Bruce D. Hammock Kenji Hashimoto
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 118(5) 2021年2月
Ketamine: From Abused Drug to Rapid-Acting Antidepressant 1-189 2020年1月
This book presents the latest data from basic research and clinical trials supporting the effectiveness of ketamine as a treatment for depression, bipolar disorder, and suicidal behavior, setting these positive findings within the context of the s...
大学院国際学術研究院