藤木亮次

研究者氏名	藤木亮次
	フジキリョウジ
URL
所属	千葉大学
部署	医学部附属病院がんゲノムセンター
職名	特任助教
学位	博士(東京大学)
科研費研究者番号	40534516
J-Global ID	202101013027886114

論文

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Tumorigenic activation around HPV integrated sites in head and neck squamous cell carcinoma.

Masato Mima Atsushi Okabe Takayuki Hoshii Takuya Nakagawa Tomoya Kurokawa Satoru Kondo Harue Mizokami Masaki Fukuyo Ryoji Fujiki Bahityar Rahmutulla Tomokazu Yoshizaki Toyoyuki Hanazawa Kiyoshi Misawa Atsushi Kaneda

International journal of cancer 152(9) 1847-1862 2023年1月

Human papillomavirus (HPV) is causally involved in the development of head and neck squamous cell carcinoma (HNSCC). The integration of HPV drives tumorigenesis through expression of oncogenic viral genes as well as genomic alterations in surround...

Characterization of the Immune Resistance of Severe Acute Respiratory Syndrome Coronavirus 2 Mu Variant and the Robust Immunity Induced by Mu Infection

Keiya Uriu Paúl Cárdenas Erika Muñoz Veronica Barragan Yusuke Kosugi Kotaro Shirakawa Akifumi Takaori-Kondo Jumpei Ito Daichi Yamasoba Izumi Kimura Mai Suganami Akiko Oide Miyabishara Yokoyama Mika Chiba So Nakagawa Jiaqi Wu Miyoko Takahashi Yasuhiro Kazuma Ryosuke Nomura Yoshihito Horisawa Kayoko Nagata Yohei Yanagida Yugo Kawai Yusuke Tashiro Atsushi Kaneda Taka Aki Nakada Motoaki Seki Ryoji Fujiki Tadanaga Shimada Kiyoshi Hirahara Koutaro Yokote Toshinori Nakayama Takashi Irie Ryoko Kawabata Nanami Morizako Takasuke Fukuhara Kenta Shimizu Kana Tsushima Haruko Kubo Terumasa Ikeda Chihiro Motozono Hesham Nasser Ryo Shimizu Yue Yuan Kazuko Kitazato Haruyo Hasebe Takamasa Ueno Akatsuki Saito Erika P. Butlertanaka Yuri L. Tanaka Kenzo Tokunaga Seiya Ozono Kenji Sadamasu Hiroyuki Asakura Isao Yoshida Mami Nagashima Kazuhisa Yoshimura Sully Márquez Belén Prado-Vivar Mónica Becerra-Wong Mateo Carvajal Gabriel Trueba Patricio Rojas-Silva Michelle Grunauer Bernardo Gutierrez Juan José Guadalupe Juan Carlos Fernández-Cadena Derly Andrade-Molina Manuel Baldeon Andrea Pinos Kei Sato

Journal of Infectious Diseases 226(7) 1200-1203 2022年10月

Background: We have recently revealed that the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) Mu variant shows a pronounced resistance to antibodies elicited by natural SARS-CoV-2 infection and vaccination. Methods: However, it remai...

Association of tumors having Epstein-Barr virus in surrounding lymphocytes with poor prognosis.

Norikazu Yogi Genki Usui Keisuke Matsusaka Masaki Fukuyo Ryoji Fujiki Motoaki Seki Shigetsugu Takano Hiroyuki Abe Teppei Morikawa Tetsuo Ushiku Masayuki Ohtsuka Atsushi Kaneda

Cancer medicine 12(2) 1122-1136 2022年6月

Infection with certain viruses is an important cause of cancer. The Pan-Cancer Analysis of Whole Genomes (PCAWG) Consortium recently analyzed the whole-genome sequencing (WGS) data from 2656 cases across 21 cancer types, and indicated that Epstein...

Virological characteristics of the SARS-CoV-2 Omicron BA.2 spike.

Daichi Yamasoba Izumi Kimura Hesham Nasser Yuhei Morioka Naganori Nao Jumpei Ito Keiya Uriu Masumi Tsuda Jiri Zahradnik Kotaro Shirakawa Rigel Suzuki Mai Kishimoto Yusuke Kosugi Kouji Kobiyama Teppei Hara Mako Toyoda Yuri L Tanaka Erika P Butlertanaka Ryo Shimizu Hayato Ito Lei Wang Yoshitaka Oda Yasuko Orba Michihito Sasaki Kayoko Nagata Kumiko Yoshimatsu Hiroyuki Asakura Mami Nagashima Kenji Sadamasu Kazuhisa Yoshimura Jin Kuramochi Motoaki Seki Ryoji Fujiki Atsushi Kaneda Tadanaga Shimada Taka-Aki Nakada Seiichiro Sakao Takuji Suzuki Takamasa Ueno Akifumi Takaori-Kondo Ken J Ishii Gideon Schreiber Hirofumi Sawa Akatsuki Saito Takashi Irie Shinya Tanaka Keita Matsuno Takasuke Fukuhara Terumasa Ikeda Kei Sato

Cell 185(12) 2103-2115 2022年6月

Soon after the emergence and global spread of the SARS-CoV-2 Omicron lineage BA.1, another Omicron lineage, BA.2, began outcompeting BA.1. The results of statistical analysis showed that the effective reproduction number of BA.2 is 1.4-fold higher...

ARID1A loss-of-function induces CpG island methylator phenotype.

Harumi Yamada Hideyuki Takeshima Ryoji Fujiki Satoshi Yamashita Shigeki Sekine Takayuki Ando Naoko Hattori Atsushi Okabe Takaki Yoshikawa Kazutaka Obama Hitoshi Katai Atsushi Kaneda Toshikazu Ushijima

Cancer letters 532 215587-215587 2022年4月

The CpG island methylator phenotype (CIMP) is associated with prognosis and drug sensitivity in multiple cancer types. In gastric cancer, the CIMP is closely associated with Epstein-Barr virus (EBV) infection and AT-rich interactive domain 1A (ARI...