Xiayun Wan   Akifumi Eguchi   Akemi Sakamoto   Yuko Fujita   Yong Yang   Youge Qu   Masahiko Hatano   Chisato Mori   Kenji Hashimoto   
Brain, behavior, & immunity - health 27 100573-100573 2023年2月
The spleen is a key immune-related organ that plays a role in communication between the brain and the immune system through the brain-spleen axis and brain-gut-microbiota axis. However, how the gut microbiota affects spleen and brain function rema...
Yong Yang   Akifumi Eguchi   Xiayun Wan   Lijia Chang   Xingming Wang   Youge Qu   Chisato Mori   Kenji Hashimoto   
Progress in neuro-psychopharmacology & biological psychiatry 120 110652-110652 2023年1月
The α7 subtype of the nicotinic acetylcholine receptor (α7 nAChR: coded by Chrna7) is known to regulate the cholinergic ascending anti-inflammatory pathway. We previously reported that Chrna7 knock-out (KO) mice show depression-like behaviors thro...
Dichlorodiphenyltrichloroethane (DDT) is an organochlorine insecticide used worldwide. Several studies have reported the toxic effects of DDT and its metabolites on steroid hormone biosynthesis; however, its environmental effects are not well unde...
Youge Qu   Akifumi Eguchi   Xiayun Wan   Li Ma   Lijia Chang   Jiajing Shan   Yong Yang   Chisato Mori   Kenji Hashimoto   
Psychiatry research 320 115020-115020 2022年12月
3,4-Methylenedioxymethamphetamine (MDMA), the most widely used illicit compound worldwide, is the most attractive therapeutic drug for post-traumatic stress disorder (PTSD). Recent observational studies of US adults demonstrated that lifetime MDMA...
Xingming Wang   Akifumi Eguchi   Yong Yang   Lijia Chang   Xiayun Wan   Jiajing Shan   Youge Qu   Li Ma   Chisato Mori   Jianjun Yang   Kenji Hashimoto   
Neurobiology of disease 176 105951-105951 2022年12月
Multiple sclerosis (MS) is the most common demyelinating disease that attacks the central nervous system. Dietary intake of cuprizone (CPZ) produces demyelination resembling that of patients with MS. Given the role of the vagus nerve in gut-microb...