医学部附属病院

研究キーワード

重症筋無力症 ,視神経脊髄炎 ,多発性硬化症 ,神経免疫

研究分野

ライフサイエンス / 神経内科学 /

経歴

12 >

2021年9月

-

現在

千葉大学医学部附属病院脳神経内科診療講師

2012年4月

-

2021年8月

千葉大学医学部附属病院脳神経内科助教

2008年10月

-

2012年3月

千葉大学医学部附属病院神経内科医員

2007年10月

-

2008年9月

国保松戸市立病院神経内科

2006年4月

-

2007年9月

千葉労災病院神経内科

学歴

2008年4月

-

2012年3月

千葉大学大学院医学薬学府先端生命科学博士課程

委員歴

重症筋無力症／ランバート・イートン筋無力症候群診療ガイドライン作成委員

受賞

12 3 >

2022年11月

日本神経治療学会優秀演題賞

2022年11月

日本神経治療学会学会賞（治療学術賞）

2022年10月

日本神経免疫学会創世賞

2018年5月

日本神経学会最優秀口演賞

2017年

International Taiwanese Congress of Neurology, Travel Award

論文

12 3 4 5 >

Therapeutic Responses to Efgartigimod for Generalized Myasthenia Gravis in Japan.

Shigeaki Suzuki Akiyuki Uzawa Yuriko Nagane Masayuki Masuda Shingo Konno Tomoya Kubota Makoto Samukawa Kei Ishizuchi Daiki Tokuyasu Hideo Handa Manato Yasuda Naoki Kawaguchi Takashi Kimura Yasushi Suzuki Takamichi Sugimoto Naoya Minami Masanori P Takahashi Hiroyuki Murai Kimiaki Utsugisawa

Neurology. Clinical practice 14(3) e200276 2024年6月

BACKGROUND AND OBJECTIVES: Efgartigimod, which has been well tolerated and efficacious in individuals with generalized myasthenia gravis (MG), is available in Japan not only for the treatment of anti-acetylcholine receptor-positive (AChR+) but als...

Markedly upregulated serum semaphorin 4A as a novel activity marker of myasthenia gravis.

Akiyuki Uzawa Manato Yasuda Hiroyuki Akamine Yosuke Onishi Hideo Handa Etsuko Ogaya Yukiko Ozawa Hiroki Masuda Masahiro Mori Satoshi Kuwabara

Scandinavian journal of immunology 99(5) e13360 2024年5月

Myasthenia gravis (MG) is an autoantibody-mediated disease of the neuromuscular junction. Semaphorin 4A (Sema4A) is involved in the activation of T cells in various inflammatory disorders. In this study, we aimed to investigate whether Sema4A is i...

Real-world experience with eculizumab and switching to ravulizumab for generalized myasthenia gravis.

Daiki Tokuyasu Shigeaki Suzuki Akiyuki Uzawa Yuriko Nagane Masayuki Masuda Shingo Konno Tomoya Kubota Makoto Samukawa Takamichi Sugimoto Kei Ishizuchi Munenori Oyama Manato Yasuda Hiroyuki Akamine Yosuke Onishi Yasushi Suzuki Naoki Kawaguchi Naoya Minami Takashi Kimura Masanori P Takahashi Hiroyuki Murai Kimiaki Utsugisawa

Annals of clinical and translational neurology 2024年4月

OBJECTIVE: Eculizumab and ravulizumab are complement protein C5 inhibitors, showing efficacy and tolerability for patients with anti-acetylcholine receptor-positive (AChR+) generalized myasthenia gravis (gMG) in phase 3 clinical trials and subsequ...

Clinical features and outcomes of patients with muscle-specific kinase antibody-positive myasthenia gravis in Japan.

Manato Yasuda Akiyuki Uzawa Satoshi Kuwabara Shigeaki Suzuki Hiroyuki Akamine Yosuke Onishi Yukiko Ozawa Naoki Kawaguchi Tomoya Kubota Masanori P Takahashi Yasushi Suzuki Genya Watanabe Takashi Kimura Takamichi Sugimoto Makoto Samukawa Naoya Minami Masayuki Masuda Shingo Konno Yuriko Nagane Kimiaki Utsugisawa

Journal of neuroimmunology 385 578241-578241 2023年11月

This study included 51 patients with muscle-specific kinase antibody-positive myasthenia gravis (MuSK-MG) from a Japanese multicenter survey to examine clinical features and outcomes. Median onset age was 37 years and female predominance was obser...

Activation of the classical complement pathway in myasthenia gravis with acetylcholine receptor antibodies.

Yukiko Ozawa Akiyuki Uzawa Yosuke Onishi Manato Yasuda Yuta Kojima Satoshi Kuwabara

Muscle & nerve 68(5) 798-804 2023年11月

INTRODUCTION/AIMS: Myasthenia gravis (MG) is an autoimmune disease affecting the neuromuscular junction (NMJ) of skeletal muscle. Complement activation is one of the mechanisms by which anti-acetylcholine receptor (anti-AChR) autoantibodies reduce...