Highly regio- and stereoselective homodimerizative [2 + 2] cycloaddition of allenamides under nickel catalysis was developed. Xantphos is an essential ligand to give “tail to tail” products and DFT studies revealed that oxidative addition between ...
<jats:p>Vinylallenes have been recognized as versatile C2 and C4 components for nickel-catalyzed intramolecular [4+2] and [2+2] cycloadditions. The former reaction was promoted by a Ni(0) complex (up to quantitative yield),...</jats:p>
Ruirong Yi Yoshifumi Ohno Zheng Tian Shuhan Guo Weiwei Chen Xue Ma Nan Nwe Win Qisen Li Majid Vahed Kengo Saito Shingo Nakamoto Akiko Suganami Naohisa Isegawa Keisuke Yoshida Shinji Harada Yutaka Tamura Atsushi Nishida Hiroshi Shirasawa
Oncology reports 44(6) 2770-2782 2020年12月 [査読有り]
Targeting cell‑cycle regulation to hinder cancer cell proliferation is a promising anticancer strategy. The present study investigated the effects of a novel sulfonamide, CCL113, on cell cycle progression in cancer cell lines (HeLa and HepG2), a n...
We have established aromatic enamide-ene metathesis to give highly substituted indole derivatives. This is a new method for the preparation of chiral 2-trans-cyclopropyl indoles, which successfully led to our H 4 antagonist candidates. Based on th...
大学院国際学術研究院