Infectious diseases caused by bacteria have significant impacts on global public health. During infection, pathogenic bacteria deliver a variety of virulence factors, called effectors, into host cells. The Shigella effector IpaH9.8 functions as an...
Hiroshi Ashida Michinaga Ogawa Minsoo Kim Hitomi Mimuro Chihiro Sasakawa
Nature Chemical Biology 8(1) 36-45 2012年1月
The gut mucosa acts as a barrier against microbial invaders, whereas resident commensal and foreign invading bacteria interact intimately with the gut epithelium and influence the host cellular and immune systems. The epithelial barrier serves as ...
Proceedings of the National Academy of Sciences of the United States of America 107 7419-7424 2010年4月
The indigenous bacteria create natural cohabitation niches together with mucosal Abs in the gastrointestinal (GI) tract. Here we report that opportunistic bacteria, largely Alcaligenes species, specifically inhabit host Peyer's patches (PPs) ...
We previously showed that oral immunization of mice with a rice-based vaccine expressing cholera toxin (CT) B subunit (Muco-Rice-CT-B) induced CT-specific immune responses with toxin-neutralizing activity in both systemic and mucosal compartments....
大学院国際学術研究院