Ubiquitylation is a crucial post-translational protein modification that regulates several cellular processes in eukaryotes, including inflammatory responses, endocytic trafficking and the cell cycle. Importantly, ubiquitylation also has a central...
Irving AT   Mimuro H   Kufer TA   Lo C   Wheeler R   Turner LJ   Thomas BJ   Malosse C   Gantier MP   Casillas LN   Votta BJ   Bertin J   Boneca IG   Sasakawa C   Philpott DJ   Ferrero RL   Kaparakis-Liaskos M   
Suzuki S   Franchi L   He Y   Muñoz-Planillo R   Mimuro H   Suzuki T   Sasakawa C   Núñez G   
Recognition of intracellular pathogenic bacteria by members of the nucleotide-binding domain and leucine-rich repeat containing (NLR) family triggers immune responses against bacterial infection. A major response induced by several Gram-negative b...
Akira Nishide   Minsoo Kim   Kenji Takagi   Ai Himeno   Takahito Sanada   Chihiro Sasakawa   Tsunehiro Mizushima   
JOURNAL OF MOLECULAR BIOLOGY 425(15) 2623-2631 2013年8月 [査読有り]
Ubc13 is a ubiquitin-conjugating enzyme that plays a key role in the nuclear factor-kappa B signal transduction pathway in human diseases. The Shigella flexneri effector OspI affects inflammatory responses by catalyzing the deamidation of a specif...
Hiroshi Ashida   Minsoo Kim   Chihiro Sasakawa   
CELLULAR MICROBIOLOGY 16(12) 1757-1766 2014年12月
Host cells deploy multiple defences against microbial infection. One prominent host defence mechanism, the death of infected cells, plays a pivotal role in clearing damaged cells, eliminating pathogens, removing replicative niches, exposing intrac...