Normal sperm flagellar shape and movement are essential for fertilization. The integral protein outer dense fiber 4 (ODF4) localizes to ODFs, but its function remains unclear. Adenylate kinase (AK) is a phosphotransferase that catalyzes ...
Lysyl hydroxylase 2 (LH2) is an enzyme that catalyzes the hydroxylation of lysine (Lys) residues in fibrillar collagen telopeptides, a critical post-translational modification for the stability of intermolecular cross-links. Though abnormal LH2 ac...
Deleted in lung and esophageal cancer 1 (DLEC1) is a tumour suppressor gene that is downregulated in various cancers in humans; however, the physiological and molecular functions of DLEC1 are still unclear. This study investigated the critical rol...
Biology of Reproduction 102(3) 750-757 2020年3月 [査読有り]
<title>Abstract</title>
The acrosome reaction is a multi-step event essential for physiological fertilization. During the acrosome reaction, gamete fusion-related factor IZUMO1 translocates from the anterior acrosome to the equatorial segment and...
Outer dense fibre 2 (Odf2 or ODF2) is a cytoskeletal protein required for flagella (tail)-beating and stability to transport sperm cells from testes to the eggs. There are infertile males, including human patients, who have a high percentage of de...
Kiyotata Toshimori   Mamiko Maekawa   Chizuru Ito   Yoshiro Toyama   Fumie Suzuki-Toyota   Dinesh K. Saxena   
Reproductive Medicine and Biology 5(2) 87-93 2006年
The immunoglobulin superfamily (IgSF) proteins are expressed on the plasma membrane between Sertoli cells and germ cells in the testis. IgSF proteins are specifically present at the apical Sertoli-germ cell junction, that is, ectoplasmic specializ...
S Kai   K Yakushiji   M Yamauchi   C Ito   M Kuwajima   Y Osada   K Toshimori   
TISSUE & CELL 37(4) 309-315 2005年8月
Among the organic cation transporters, OCTN2 is identified as the most important carnitine transporter owing to the ability to transport carnitine. Although the OCTN2 is previously found in various tissues, there have been no reports showing the O...
MOLECULAR AND CELLULAR BIOLOGY 25(16) 7107-7119 2005年8月
We cloned a testis-specific cDNA from mice that encodes a histone H1-like, haploid germ cell-specific nuclear protein designated HANP1/H1T2. The HANP1/H1T2 protein was specifically localized to the nuclei of murine spermatids during differentiatio...
Y Tabuchi   Y Toyama   K Toshimor   M Komiyama   C Mori   T Kondo   
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 329(3) 812-823 2005年4月
A conditionally immortalized epididymis caput cell line, MEPC5, was established by infecting primary cultured mouse epididymis caput cells with a temperature-sensitive simian virus 40 large T-antigen. At a permissive temperature of 33 degrees C, t...