To identify upregulated genes during the development of spermatozoa, we performed PCR-selected subtraction analysis of testes RNA samples from 10-day-old and 12-week-old shrews. A transcript, highly homologous to two mouse transcripts, Ms4a13-1 an...
Yixin Dong Kyo-ichi Isono Kazuyuki Ohbo Takaho A. Endo Osamu Ohara Mamiko Maekawa Yoshiro Toyama Chizuru Ito Kiyotaka Toshimori Kristian Helin Narumi Ogonuki Kimiko Inoue Atsuo Ogura Kazutsune Yamagata Issay Kitabayashi Haruhiko Koseki
MOLECULAR AND CELLULAR BIOLOGY 37(19) 2017年10月 [査読有り]
Global histone hyperacetylation is suggested to play a critical role for replacement of histones by transition proteins and protamines to compact the genome during spermiogenesis. However, the underlying mechanisms for hyperacetylation-mediated hi...
JOURNAL OF BIOLOGICAL CHEMISTRY 292(29) 12065-12076 2017年7月 [査読有り]
Docosahexaenoic acid (DHA) is one of the essential omega-3 polyunsaturated fatty acids with a wide range of physiological roles important for human health. For example, DHA renders cell membranes more flexible and is therefore important for cellul...
Takehiko Oami Eizo Watanabe Masahiko Hatano Satoshi Sunahara Lisa Fujimura Akemi Sakamoto Chizuru Ito Kiyotaka Toshimori Shigeto Oda
Critical Care Medicine 45(1) e77-e85 2017年1月 [査読有り]
Objective: While type 1 programmed cell death (apoptosis) of T cells leads to immunosuppression in sepsis, a crosstalk between apoptosis and autophagy (type 2 programmed cell death) has not been shown. The aim of this study is to elucidate the det...
Shin-ya Maruyama Momoe Ito Yuusuke Ikami Yu Okitsu Chizuru Ito Kiyotaka Toshimori Wataru Fujii Keiichiro Yogo
SCIENTIFIC REPORTS 6 36468 2016年11月 [査読有り]
We previously identified solute carrier 22a14 (Slc22a14) as a spermatogenesis-associated transmembrane protein in mice. Although Slc22a14 is a member of the organic anion/ cation transporter family, its expression profile and physiological role ha...
大学院国際学術研究院