Researcher List >> Yoshihiro Onouchi

Yoshihiro Onouchi

Name	Yoshihiro Onouchi
URL
Affiliation	千葉大学
Section	大学院医学研究院公衆衛生学
Job title	教授
J-Global ID	201801020026695650

Research Interests

Pediatrics ,Genetics ,Kawasaki Disease

Research Areas

Life sciences / Genetics /

Research History

12 >

Mar 2020

Today

Chiba University Graduate School of Medicine Department of Public Health Professor

Nov 2012

Feb 2020

Chiba University Graduate School of Medicine Department of Public Health Associate Professor

Jul 2011

Oct 2012

Chiba Unicersity Graduate School of Medicine Department of Public Health Lecturer

Mar 2008

Jun 2011

RIKEN Center for Genomic Medicine Laboratory for Cardiovascular Diseases Senior Research Scientist

Apr 2005

Mar 2008

RIKEN SNP Research Center Laboratory for Gastrointestinal Diseases Senior Research Scientist

Education

Apr 1997

Mar 2001

大阪大学大学院医学研究科博士課程

Apr 1988

Mar 1994

Osaka University Faculty of Medicine Medical School

Committee Memberships

Today

関東川崎病研究会運営委員

Today

日本川崎病学会運営委員

Nov 2013

Nov 2019

日本人類遺伝学会評議員

Awards

12 >

Nov 2018

Kawasaki Disease Society of India, Dr. Tomisaku Kawasaki Oration,Genetic studies of Kawasaki Disease toward understanding of the pathogenesis and implementation of precision medicine
Yoshihiro Onouchi

2015

International Kawasaki Disease Symposium, Poster Presentation Award,Variations in ORAI1 gene associated with Kawasaki disease
Yoshihiro Onouchi

2014

千葉医学会, 千葉医学会賞,川崎病の遺伝的背景の解明
尾内善広

Oct 2012

日本川崎病学会, 川崎賞,A genome-wide association study identified three new risk loci for Kawasaki disease
尾内善広

2011

International Kawasaki Disease Symposium, Yuki-Lynn Takahashi Memorial Lecture,Genome-wide association study identified new susceptibility loci for Kawasaki disease -We have found milestones but still have far to go-
Yoshihiro Onouchi

Papers

12 3 4 5 >

Impact of the coronavirus disease 2019 pandemic on primary and metastatic lung cancer treatments in Japan: A nationwide study using an interrupted time series analysis

Misuzu Fujita Takehiko Fujisawa Kiminori Suzuki Kengo Nagashima Tokuzo Kasai Hideyuki Hashimoto Kazuya Yamaguchi Yoshihiro Onouchi Daisuke Sato Akira Hata

Cancer Epidemiology 90 102549-102549 Jun 2024

Impact of the COVID‐19 pandemic on gastric surgery in Japan: A nationwide study using interrupted time‐series analyses

Misuzu Fujita Kazuya Yamaguchi Kengo Nagashima Kiminori Suzuki Tokuzo Kasai Hideyuki Hashimoto Yoshihiro Onouchi Daisuke Sato Takehiko Fujisawa Akira Hata

Journal of Gastroenterology and Hepatology Mar 2024

Abstract

Background and Aim

Changes in the number of surgeries for gastric cancer during the coronavirus disease 2019 (COVID‐19) pandemic have been reported, but data are insufficient to understand the impact at the national level. This study ai...

Case Report: Identification of a CARD8 variant in all three patients with PFAPA syndrome complicated with Kawasaki disease.

Haruhiko Nakamura Atsuo Kikuchi Hideyuki Sakai Miki Kamimura Yohei Watanabe Ryoichi Onuma Jun Takayama Gen Tamiya Yoichi Mashimo Ryota Ebata Hiromichi Hamada Tomohiro Suenaga Yoshihiro Onouchi Satoru Kumaki

Frontiers in pediatrics 12 1340263-1340263 2024

BACKGROUND: Periodic fever, aphthous stomatitis, pharyngitis, and cervical adenitis (PFAPA syndrome), and Kawasaki disease (KD) are both considered to be disorders of the innate immune system, and the potential role of inflammasome activation in t...

Changes in colorectal cancer treatment during the COVID-19 pandemic in Japan: Interrupted time-series analysis using the National Database of Japan

Misuzu Fujita Kazuya Yamaguchi Kengo Nagashima Kiminori Suzuki Tokuzo Kasai Hideyuki Hashimoto Yoshihiro Onouchi Daisuke Sato Takehiko Fujisawa Akira Hata

Cancer Epidemiology 85 102391-102391 Aug 2023

Impact of coronavirus disease 2019 pandemic on breast cancer surgery using the National Database of Japan

Misuzu Fujita Hideyuki Hashimoto Kengo Nagashima Kiminori Suzuki Tokuzo Kasai Kazuya Yamaguchi Yoshihiro Onouchi Daisuke Sato Takehiko Fujisawa Akira Hata

Scientific Reports 13(1) Mar 2023

Abstract

Various countries have reported a decrease in breast cancer surgeries during the coronavirus disease 2019 (COVID-19) pandemic; however, inconsistent results have been reported in Japan. This study revealed changes in the number of surger...

Misc.

12 3 4 5 >

A novel intron variant of FBN1 leading to isolated ectopia lentis

清水規宏尾内善広真下陽一横内裕敬馬場隆之

日本眼科学会雑誌 127 2023

Machado-Joseph病におけるCAGリピート伸長と家族歴の関係

澤井摂石毛崇之宇津野恵美関根瑞香杉山淳比古尾内善広榊原隆次松下一之市川智彦桑原聡

臨床神経学 62(Suppl.) S287-S287 Oct 2022

【川崎病の今】病因・病態解明遺伝子解析から

尾内善広

小児内科 53(1) 17-23 Jan 2021

＜Key Points＞(1)川崎病は遺伝、環境が関与する多因子疾患であり、ゲノムワイド研究により複数の川崎病罹患感受性遺伝子が特定されている。(2)罹患感受性遺伝子の情報からB細胞の川崎病における役割の重要性が注目されている。(3)遺伝要因の知見からシクロスポリンを併用し強化した初期治療法の開発に結びついている。(著者抄録)

【川崎病-診断と治療の新展開】病因遺伝研究からの知見

尾内善広

カレントテラピー 38(10) 948-953 Oct 2020

川崎病は感染を含む環境要因に年齢や遺伝要因、性別などの個人の要因が絡む多因子疾患であり、遺伝要因の探索が国内外で進められている。これまでに確認された川崎病罹患感受性遺伝子の機能や、in vitroおよびin silicoの責任バリアントやその遺伝子機能への影響の予測の結果から、イノシトール3リン酸やCa2+イオンが関与する分子パスウェイの重要性と、B細胞の関与という視点がもたらされている。前者の知見はシクロスポリンを用いた新規治療法の開発へと結びつき、多因子疾患の遺伝研究の成果が臨床に還元...

川崎病(冠動脈炎)の病態と治療川崎病の遺伝学からみたシクロスポリン療法

尾内善広

脈管学 60(Suppl.) S100-S100 Oct 2020