関直彦

研究者氏名	関直彦
	セキナオヒコ
通称等の別名	千葉大学大学院医学研究院機能ゲノム学
URL
所属	千葉大学
部署	大学院医学研究院
職名	准教授
学位	医学博士(千葉大学)
科研費研究者番号	50345013
J-Global ID	200901004712087610

プロフィール

1991年千葉大学大学院医学研究科博士課程修了（医学博士）
1991年科学技術庁放射線医学総合研究所客員研究官
1992年かずさDNA研究所遺伝子構造第１研究室研究員
1999年ヘリックス研究所第３研究部門主任研究員
2002年千葉大学大学院医学研究院研究准教授
2015年千葉大学大学院医学研究院准教授

研究キーワード

腫瘍学 ,マイクロRNA ,機能性RNA ,ゲノム医学

研究分野

ライフサイエンス / 腫瘍生物学 /

論文

<2 345 6 >

miR-874によるメバロン酸経路の抑制を介した乳がん抑制機構の解明

橋本直子山形一行横山真隆石曉彦村田和貴関直彦田中知明

日本内分泌学会雑誌 98(1) 403-403 2022年4月

Identification of Tumor-Suppressive miR-30e-3p Targets: Involvement of SERPINE1 in the Molecular Pathogenesis of Head and Neck Squamous Cell Carcinoma.

Chikashi Minemura Shunichi Asai Ayaka Koma Ikuko Kase-Kato Nozomi Tanaka Naoko Kikkawa Atsushi Kasamatsu Hidetaka Yokoe Toyoyuki Hanazawa Katsuhiro Uzawa Naohiko Seki

International journal of molecular sciences 23(7) 2022年3月 [査読有り]

Recently, our studies revealed that some passenger strands of microRNAs (miRNAs) were closely involved in cancer pathogenesis. Analysis of miRNA expression signatures showed that the expression of miR-30e-3p (the passenger strand of pre-miR-30e) w...

Impact of miR-1/miR-133 Clustered miRNAs: PFN2 Facilitates Malignant Phenotypes in Head and Neck Squamous Cell Carcinoma.

Shunichi Asai Ayaka Koma Nijiro Nohata Takashi Kinoshita Naoko Kikkawa Mayuko Kato Chikashi Minemura Katsuhiro Uzawa Toyoyuki Hanazawa Naohiko Seki

Biomedicines 10(3) 2022年3月 [査読有り]

Based on our original RNA sequence-based microRNA (miRNA) signatures of head and neck squamous cell carcinoma (HNSCC), it was revealed that the expression levels of miR-1-3p, miR-206, miR-133a-3p, and miR-133b were significantly suppressed in canc...

Regulation of Oncogenic Targets by Tumor-Suppressive miR-150-3p in Lung Squamous Cell Carcinoma.

Keiko Mizuno Kengo Tanigawa Shunsuke Misono Takayuki Suetsugu Hiroki Sanada Akifumi Uchida Minami Kawano Kentaro Machida Shunichi Asai Shogo Moriya Hiromasa Inoue Naohiko Seki

Biomedicines 9(12) 2021年12月 [査読有り]

Several recent studies have shown that both strands of certain miRNAs derived from miRNA duplexes are involved in cancer pathogenesis. Our own recent studies revealed that both strands of the miR-150 duplex act as tumor-suppressive miRNAs in lung ...

Identification of miR-199-5p and miR-199-3p Target Genes: Paxillin Facilities Cancer Cell Aggressiveness in Head and Neck Squamous Cell Carcinoma.

Nozomi Tanaka Chikashi Minemura Shunichi Asai Naoko Kikkawa Takashi Kinoshita Sachi Oshima Ayaka Koma Atsushi Kasamatsu Toyoyuki Hanazawa Katsuhiro Uzawa Naohiko Seki

Genes 12(12) 2021年11月 [査読有り]

Our previous study revealed that the miR-199 family (miR-199a-5p/-3p and miR-199b-5p/-3p) acts as tumor-suppressive miRNAs in head and neck squamous cell carcinoma (HNSCC). Furthermore, recent studies have indicated that the passenger strands of m...