Naohiko Seki

Name	Naohiko Seki
Alternative Names	Chiba University Graduate School of Medicine Functional Genomics
URL
Affiliation	Chiba University
Section	Graduate School of Medicine
Job title	准教授
Degree	医学博士(千葉大学)
Research funding number	50345013
J-Global ID	200901004712087610

Research Interests

腫瘍学 ,マイクロRNA ,機能性RNA ,ゲノム医学

Research Areas

Life sciences / Tumor biology /

Papers

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Molecular Pathogenesis of the Coronin Family: CORO2A Facilitates Migration and Invasion Abilities in Oral Squamous Cell Carcinoma.

Ikuko Kase-Kato Shunichi Asai Chikashi Minemura Kenta Tsuneizumi Sachi Oshima Ayaka Koma Atsushi Kasamatsu Toyoyuki Hanazawa Katsuhiro Uzawa Naohiko Seki

International journal of molecular sciences 22(23) Nov 2021 [Refereed]

In humans, the coronin family is composed of seven proteins containing WD-repeat domains that regulate actin-based cellular processes. Some members of the coronin family are closely associated with cancer cell migration and invasion. The Cancer Ge...

Impact of Oncogenic Targets Controlled by Tumor-Suppressive miR-30a-5p in Pancreatic Ductal Adenocarcinoma.

Pramod Nepal Yuto Hozaka Takako Tanaka Masumi Wada Shunichi Asai Chikashi Minemura Tetsuya Idichi Takaaki Arigami Hiroshi Kurahara Naohiko Seki Takao Ohtsuka

Anticancer research 41(10) 4821-4836 Oct 2021 [Refereed]

BACKGROUND/AIM: Our recent miRNA analyses revealed that miR-30a-5p has tumor-suppressive activity in pancreatic ductal adenocarcinoma (PDAC). Herein, we sought to identify tumor-suppressive genes controlled by miR-30a-5p, emphasizing on genes that...

Impact of Oncogenic Targets by Tumor-Suppressive miR-139-5p and miR-139-3p Regulation in Head and Neck Squamous Cell Carcinoma.

Ayaka Koma Shunichi Asai Chikashi Minemura Sachi Oshima Takashi Kinoshita Naoko Kikkawa Keiichi Koshizuka Shogo Moriya Atsushi Kasamatsu Toyoyuki Hanazawa Katsuhiro Uzawa Naohiko Seki

International journal of molecular sciences 22(18) Sep 2021 [Refereed]

We newly generated an RNA-sequencing-based microRNA (miRNA) expression signature of head and neck squamous cell carcinoma (HNSCC). Analysis of the signature revealed that both strands of some miRNAs, including miR-139-5p (the guide strand) and miR...

RNA-Sequencing Based microRNA Expression Signature of Colorectal Cancer: The Impact of Oncogenic Targets Regulated by miR-490-3p.

Yuto Hozaka Yoshiaki Kita Ryutaro Yasudome Takako Tanaka Masumi Wada Tetsuya Idichi Kan Tanabe Shunichi Asai Shogo Moriya Hiroko Toda Shinichiro Mori Hiroshi Kurahara Takao Ohtsuka Naohiko Seki

International journal of molecular sciences 22(18) Sep 2021 [Refereed]

To elucidate novel aspects of the molecular pathogenesis of colorectal cancer (CRC), we have created a new microRNA (miRNA) expression signature based on RNA-sequencing. Analysis of the signature showed that 84 miRNAs were upregulated, and 70 were...

Identification of Tumor Suppressive Genes Regulated by miR-31-5p and miR-31-3p in Head and Neck Squamous Cell Carcinoma.

Sachi Oshima Shunichi Asai Naohiko Seki Chikashi Minemura Takashi Kinoshita Yusuke Goto Naoko Kikkawa Shogo Moriya Atsushi Kasamatsu Toyoyuki Hanazawa Katsuhiro Uzawa

International journal of molecular sciences 22(12) Jun 2021 [Refereed]

We identified the microRNA (miRNA) expression signature of head and neck squamous cell carcinoma (HNSCC) tissues by RNA sequencing, in which 168 miRNAs were significantly upregulated, including both strands of the miR-31 duplex (miR-31-5p and miR-...