大学院医学研究院

Research Interests

気管支喘息 ,真菌感染 ,シグナル伝達 ,好酸球 ,遺伝子 ,組織局在記憶T細胞 ,肺組織常在性T細胞 ,肺線維症 ,Immunology

Research Areas

Life sciences / Respiratory medicine /
Life sciences / Immunology /

Research History

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Apr 2022

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Today

Chiba University

Apr 2016

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Mar 2022

Chiba University Graduate School of Medicine

Apr 2013

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Mar 2016

Chiba University Graduate School of Medicine

Jan 2012

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Mar 2013

米国国立衛生研究所日本学術振興会海外特別研究員(NIH)

Nov 2009

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Dec 2011

米国国立衛生研究所 Visiting Fellow

Committee Memberships

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Apr 2023

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Today

日本呼吸器学会細胞・分子生物学学術部会プログラム委員

Oct 2022

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Today

日本アレルギー学会第7期委員会委員

Apr 2019

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Today

日本アレルギー学会代議員

Dec 2013

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Today

日本免疫学会評議員

Jun 2021

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Oct 2022

日本アレルギー学会第6期委員会委員

Awards

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2018

日本医師会, 日本医師会医学研究奨励賞
平原潔

2017

International Cytokine & Interferon Society, Seymour and Vivian Milstein Young Investigator Award
Kiyoshi Hirahara

2016

千葉大学, 千葉大学先進科学賞
平原潔

2016

千葉医学会, 千葉医学会賞
平原潔

2015

日本免疫学会, 日本免疫学会研究奨励賞
平原潔

Papers

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Suppression of Type I Interferon Signaling in Myeloid Cells by Autoantibodies in Severe COVID-19 Patients

Ami Aoki Chiaki Iwamura Masahiro Kiuchi Kaori Tsuji Atsushi Sasaki Takahisa Hishiya Rui Hirasawa Kota Kokubo Sachiko Kuriyama Atsushi Onodera Tadanaga Shimada Tetsutaro Nagaoka Satoru Ishikawa Akira Kojima Haruki Mito Ryota Hase Yasunori Kasahara Naohide Kuriyama Sukeyuki Nakamura Takashi Urushibara Satoru Kaneda Seiichiro Sakao Osamu Nishida Kazuhisa Takahashi Motoko Y. Kimura Shinichiro Motohashi Hidetoshi Igari Yuzuru Ikehara Hiroshi Nakajima Takuji Suzuki Hideki Hanaoka Taka-aki Nakada Toshiaki Kikuchi Toshinori Nakayama Koutaro Yokote Kiyoshi Hirahara

Journal of Clinical Immunology 44(4) Apr 2024 [Refereed]

Abstract

Purpose

Auto-antibodies (auto-abs) to type I interferons (IFNs) have been identified in patients with life-threatening coronavirus disease 2019 (COVID-19), suggesting that the presence of auto-abs may be a risk factor for disease seve...

Hepatic ketone body regulation of renal gluconeogenesis

Ryo Hatano Eunyoung Lee Hiromi Sato Masahiro Kiuchi Kiyoshi Hirahara Yoshimi Nakagawa Hitoshi Shimano Toshinori Nakayama Tomoaki Tanaka Takashi Miki

Molecular Metabolism 101934-101934 Apr 2024 [Refereed]

Single-cell RNA sequencing of submandibular gland reveals collagen type XV-positive fibroblasts as a disease-characterizing cell population of IgG4-related disease.

Shigeru Tanaka Takuya Yamamoto Arifumi Iwata Masahiro Kiuchi Kota Kokubo Tomohisa Iinuma Takahiro Sugiyama Toyoyuki Hanazawa Kiyoshi Hirahara Kei Ikeda Hiroshi Nakajima

Arthritis research & therapy 26(1) 55-55 Feb 2024 [Refereed]

OBJECTIVES: IgG4-related disease (IgG4-RD) is a systemic autoimmune disease with an unknown etiology, affecting single/multiple organ(s). Pathological findings include the infiltration of IgG4-producing plasma cells, obliterative phlebitis, and st...

The USP7-STAT3-granzyme-Par-1 axis regulates allergic inflammation by promoting differentiation of IL-5-producing Th2 cells.

Jin Kumagai Masahiro Kiuchi Kota Kokubo Hiroyuki Yagyu Masahiro Nemoto Kaori Tsuji Ken Nagahata Atsushi Sasaki Takahisa Hishiya Miki Onoue Rie Shinmi Yuri Sonobe Tomohisa Iinuma Syuji Yonekura Jun Shinga Toyoyuki Hanazawa Haruhiko Koseki Toshinori Nakayama Koutaro Yokote Kiyoshi Hirahara

Proceedings of the National Academy of Sciences of the United States of America 120(49) e2302903120 Dec 2023 [Refereed]

Uncontrolled type 2 immunity by type 2 helper T (Th2) cells causes intractable allergic diseases; however, whether the interaction of CD4+ T cells shapes the pathophysiology of allergic diseases remains unclear. We identified a subset of Th2 cells...

Pathogenic helper T cells as the novel therapeutic targets for immune-mediated intractable diseases

Atsushi Onodera Kota Kokubo Mikiko Okano Miki Onoue Masahiro Kiuchi Chiaki Iwamura Tomohisa Iinuma Motoko Y. Kimura Nobuyuki Ebihara Toyoyuki Hanazawa Toshinori Nakayama Kiyoshi Hirahara

Pharmacology & Therapeutics 247 108445-108445 Jul 2023 [Refereed]