Ryo Koyama-Nasu Motoko Y Kimura Masahiro Kiuchi Ami Aoki Yangsong Wang Yukiyoshi Mita Ichita Hasegawa Yukihiro Endo Atsushi Onodera Kiyoshi Hirahara Shinichiro Motohashi Toshinori Nakayama
Cancer immunology research May 2023 [Refereed]
Tumor-specific CD8+ T cells play a pivotal role in anti-tumor immunity and are a key target of immunotherapeutic approaches. Intratumoral CD8+ T cells are heterogeneous; Tcf1+ stem-like CD8+ T cells give rise to their cytotoxic progeny - Tim-3+ te...
Tertiary lymphoid structures (TLSs) are ectopic lymphoid tissues that drive antigen-specific immune responses at sites of chronic inflammation. Unlike secondary lymphoid organs such as lymph nodes, TLSs lack capsules and have their own unique char...
Proceedings of the National Academy of Sciences of the United States of America 120(2) e2218345120 Jan 2023 [Refereed]
CD4+ memory T cells are central to long-lasting protective immunity and are involved in shaping the pathophysiology of chronic inflammation. While metabolic reprogramming is critical for the generation of memory T cells, the mechanisms controlling...
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