Type 2 helper T (Th2) cells, a subset of CD4+ T cells, play an important role in the host defense against pathogens and allergens by producing Th2 cytokines, such as interleukin-4 (IL-4), IL-5, and IL-13, to trigger inflammatory respons...
In bronchial asthma patients, mucous cell metaplasia (MCM) and fibrosis occur in the bronchial epithelium and interstitium, respectively. The mucus and collagen fibers are identified by Periodic acid-Schiff stain (PAS) or Sirius red stai...
Kenta Shinoda   Andrea Choe   Kiyoshi Hirahara   Masahiro Kiuchi   Kota Kokubo   Tomomi Ichikawa   Jason S. Hoki   Akane S. Suzuki   Neelanjan Bose   Judith A. Appleton   Raffi V. Aroian   Frank C. Schroeder   Paul W. Sternberg   Toshinori Nakayama   
Proceedings of the National Academy of Sciences 119(9) 2022年3月 [査読有り]
Significance
Animal proof-of-concept studies have shown that roundworms have a protective effect against immune-dysregulated disorders, but it has been difficult to study in human trials without individual nematode-derived molecules to develop a...
International Immunology 33(12) 699-704 2021年11月 [査読有り]
<title>Abstract</title>
CD4+ T cells not only direct immune responses against infectious micro-organisms but are also involved in the pathogenesis of inflammatory diseases. In the last two to three decades, various researchers have identified and...