Zhoujie Ding Anna Bergman Christian Rutemark Rika Ouchida Hiroshi Ohno Ji-Yang Wang Birgitta Heyman
PLoS ONE 8(11) e81299 2013年11月 [査読有り]
IgM antibodies specific for a certain antigen can enhance antibody responses when administered together with this antigen, a process believed to require complement activation by IgM. However, recent data show that a knock-in mouse strain, Cμ13, wh...
MOLECULAR AND CELLULAR BIOLOGY 32(21) 4462-4471 2012年11月 [査読有り]
The expression of the pre-B cell receptor (BCR) is confined to the early stage of B cell development, and its dysregulation is associated with anomalies of B-lineage cells, including leukemogenesis. Previous studies suggested that the pre-BCR sign...
Rika Ouchida Hiromi Mori Koji Hase Hiroyuki Takatsu Tomohiro Kurosaki Takeshi Tokuhisa Hiroshi Ohno Ji-Yang Wang
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 109(40) E2699-E2706 2012年10月 [査読有り]
IgM antibodies have been known for decades to enhance humoral immune responses in an antigen-specific fashion. This enhancement has been thought to be dependent on complement activation by IgM-antigen complexes; however, recent genetic studies ren...
大学院国際学術研究院