Zhongwei Zhang Izumi Tanaka Rika Nakahashi-Ouchida Peter B Ernst Hiroshi Kiyono Yosuke Kurashima
Seminars in immunopathology Jan 2024
Glycoprotein 2 (GP2) is a widely distributed protein in the digestive tract, contributing to mucosal barrier maintenance, immune homeostasis, and antigen-specific immune response, while also being linked to inflammatory bowel disease (IBD) pathoge...
Cationic cholesteryl-group-bearing pullulan nanogel (cCHP-nanogel) is an effective drug-delivery system for nasal vaccines. However, cCHP-nanogel-based nasal vaccines might access the central nervous system due to its close proximity via the olfac...
Shingo Umemoto Rika Nakahashi-Ouchida Yoshikazu Yuki Shiho Kurokawa Tomonori Machita Yohei Uchida Hiromi Mori Tomoyuki Yamanoue Takehiko Shibata Shin-Ichi Sawada Kazuya Ishige Takashi Hirano Kohtaro Fujihashi Kazunari Akiyoshi Yosuke Kurashima Daisuke Tokuhara Peter B Ernst Masashi Suzuki Hiroshi Kiyono
NPJ vaccines 8(1) 106-106 Jul 2023
Respiratory syncytial virus (RSV) is a leading cause of upper and lower respiratory tract infection, especially in children and the elderly. Various vaccines containing the major transmembrane surface proteins of RSV (proteins F and G) have been t...
Trends in Molecular Medicine 29(2) 124-140 Nov 2022
Nasal vaccines induce pathogen-specific dual protective immunity at mucosal surfaces and systemically throughout the body. Consequently, nasal vaccines both prevent pathogen invasion and reduce disease severity. Because of these features, nasal va...
Nontypeable Haemophilus influenzae (NTHi) strains form a major group of pathogenic bacteria that colonizes the nasopharynx and causes otitis media in young children. At present, there is no licensed vaccine for NTHi. Because NTHi colonizes the upp...
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