研究者氏名	三木隆司

URL
所属	千葉大学
部署	大学院医学研究院代謝生理学
職名	教授
学位	博士（医学）（千葉大学）
J-Global ID	200901084204686804

研究キーワード

インスリン ,肥満症 ,糖尿病

学歴

1993年4月

1997年3月

千葉大学大学院医学研究院

1982年4月

1988年3月

千葉大学医学部

論文

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Lecithin Inclusion by α-Cyclodextrin Activates SREBP2 Signaling in the Gut and Ameliorates Postprandial Hyperglycemia

Eunyoung Lee Xilin Zhang Tomoe Noda Junki Miyamoto Ikuo Kimura Tomoaki Tanaka Kenichi Sakurai Ryo Hatano Takashi Miki

International Journal of Molecular Sciences 22(19) 10796-10796 2021年10月 [査読有り]

Background: α-cyclodextrin (α-CD) is one of the dietary fibers that may have a beneficial effect on cholesterol and/or glucose metabolism, but its efficacy and mode of action remain unclear. Methods: In the present study, we examined the anti-hype...

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GPR52 accelerates fatty acid biosynthesis in a ligand-dependent manner in hepatocytes and in response to excessive fat intake in mice

Mitsuo Wada Kayo Yukawa Hiroyuki Ogasawara Koichi Suzawa Tatsuya Maekawa Yoshihisa Yamamoto Takeshi Ohta Eunyoung Lee Takashi Miki

iScience 24(4) 102260-102260 2021年4月 [査読有り]

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Diet-Induced Obese Mice and Leptin-Deficient Lepob/ob Mice Exhibit Increased Circulating GIP Levels Produced by Different Mechanisms

Eunyoung Lee Emily L. Miedzybrodzka Xilin Zhang Ryo Hatano Junki Miyamoto Ikuo Kimura Kosuke Fujimoto Satoshi Uematsu Sergio Rodriguez-Cuenca Antonio Vidal-Puig Fiona M. Gribble Frank Reimann Takashi Miki

International Journal of Molecular Sciences 20(18) 4448-4448 2019年9月 [査読有り]

As glucose-dependent insulinotropic polypeptide (GIP) possesses pro-adipogenic action, the suppression of the GIP hypersecretion seen in obesity might represent a novel therapeutic approach to the treatment of obesity. However, the mechanism of GI...

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Gut microbiota confers host resistance to obesity by metabolizing dietary polyunsaturated fatty acids.

Junki Miyamoto Miki Igarashi Keita Watanabe Shin-Ichiro Karaki Hiromi Mukouyama Shigenobu Kishino Xuan Li Atsuhiko Ichimura Junichiro Irie Yukihiko Sugimoto Tetsuya Mizutani Tatsuya Sugawara Takashi Miki Jun Ogawa Daniel J Drucker Makoto Arita Hiroshi Itoh Ikuo Kimura

Nature communications 10(1) 4007-4007 2019年9月 [査読有り]

Gut microbiota mediates the effects of diet, thereby modifying host metabolism and the incidence of metabolic disorders. Increased consumption of omega-6 polyunsaturated fatty acid (PUFA) that is abundant in Western diet contributes to obesity and...

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Deficiency of lysyl hydroxylase 2 in mice causes systemic endoplasmic reticulum stress leading to early embryonic lethality.

Kasamatsu A Uzawa K Hayashi F Kita A Okubo Y Saito T Kimura Y Miyamoto I Oka N Shiiba M Ito C Toshimori K Miki T Yamauchi M Tanzawa H

Biochemical and biophysical research communications 512(3) 486-491 2019年5月 [査読有り]

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