Journal of Diabetes Investigation 6(5) 522-526 2015年9月 [査読有り]
Adenosine triphosphate-sensitive K(+) (KATP) channels play an essential role in glucose-induced insulin secretion from pancreatic β-cells. It was recently reported that the KATP channel is also found in the enteroendocrine K-cells and L-cells that...
FUSE-binding protein (FBP)-interacting repressor (FIR) is a c-myc transcriptional suppressor. A splice variant of FIR that lacks exon 2 in the transcriptional repressor domain (FIRΔexon2) upregulates c-myc transcription by inactivating wild-type F...
Eun Young Lee Shuji Kaneko Promsuk Jutabha Xilin Zhang Susumu Seino Takahito Jomori Naohiko Anzai Takashi Miki
Journal of Endocrinology 224(3) 205-214 2015年3月 [査読有り]
Oral ingestion of carbohydrate triggers glucagon-like peptide 1 (GLP1) secretion, but the molecular mechanism remains elusive. By measuring GLP1 concentrations in murine portal vein, we found that the ATP-sensitive K+(KATP) c...
Eri Mukai Takeshi Ohta Harukiyo Kawamura Eun-Young Lee Asuka Morita Tomohiko Sasase Katsuhiro Miyajima Nobuya Inagaki Toshihiko Iwanaga Takashi Miki
Diabetes Research and Clinical Practice 106(2) 303-311 2014年11月 [査読有り]
AIMS: Spontaneously diabetic Torii (SDT) rats exhibit vascular abnormalities in pancreatic islets as the initial changes at pre-diabetes stage (8 weeks old), which is followed by β cell deterioration. In the present study, we investigated pathophy...
大学院国際学術研究院