Insulin secretion is essential for maintenance of glucose homeostasis, but the mechanism of insulin granule exocytosis, the final step of insulin secretion, is largely unknown. Here, we investigated the role of Rim2 alpha in insulin granule exocyt...
Zvi Granot   Avital Swisa   Judith Magenheim   Miri Stolovich-Rain   Wakako Fujimoto   Elisabetta Manduchi   Takashi Miki   Jochen K. Lennerz   Christian J. Stoeckert   Oded Meyuhas   Susumu Seino   M. Alan Permutt   Helen Piwnica-Worms   Nabeel Bardeesy   Yuval Dor   
CELL METABOLISM 10(4) 296-308 2009年10月 [査読有り]
Pancreatic beta cells, organized in the islets of Langerhans, sense glucose and secrete appropriate amounts of insulin. We have studied the roles of LKB1, a conserved kinase implicated in the control of cell polarity and energy metabolism, in adul...
Epac2, a guanine nucleotide exchange factor for the small guanosine triphosphatase Rap1, is activated by adenosine 3',5'-monophosphate. Fluorescence resonance energy transfer and binding experiments revealed that sulfonylureas, widely us...
JOURNAL OF CELLULAR PHYSIOLOGY 219(3) 652-658 2009年6月 [査読有り]
cAMP is a well-known regulator of exocytosis, and cAMP-GEFII (Epac2) is involved in the potentiation of cAMP-dependent, PKA-independent regulated exocytosis in secretory cells. However, the mechanisms of its action are not fully understood. In the...