研究者氏名	三木隆司

URL
所属	千葉大学
部署	大学院医学研究院代謝生理学
職名	教授
学位	博士（医学）（千葉大学）
J-Global ID	200901084204686804

研究キーワード

インスリン ,肥満症 ,糖尿病

学歴

1993年4月

1997年3月

千葉大学大学院医学研究院

1982年4月

1988年3月

千葉大学医学部

論文

12 3 4 5 >

Hepatic ketone body regulation of renal gluconeogenesis

Ryo Hatano Eunyoung Lee Hiromi Sato Masahiro Kiuchi Kiyoshi Hirahara Yoshimi Nakagawa Hitoshi Shimano Toshinori Nakayama Tomoaki Tanaka Takashi Miki

Molecular Metabolism 101934-101934 2024年4月 [査読有り]

ダウンロード

Identification of genotype-biochemical phenotype correlations associated with fructose 1,6-bisphosphatase deficiency.

Ikki Sakuma Hidekazu Nagano Naoko Hashimoto Masanori Fujimoto Akitoshi Nakayama Takahiro Fuchigami Yuki Taki Tatsuma Matsuda Hiroyuki Akamine Satomi Kono Takashi Kono Masataka Yokoyama Motoi Nishimura Koutaro Yokote Tatsuki Ogasawara Yoichi Fujii Seishi Ogawa Eunyoung Lee Takashi Miki Tomoaki Tanaka

Communications biology 6(1) 787-787 2023年7月 [査読有り]

Fructose-1,6-bisphosphatase (FBPase) deficiency, caused by an FBP1 mutation, is an autosomal recessive disorder characterized by hypoglycemic lactic acidosis. Due to the rarity of FBPase deficiency, the mechanism by which the mutations cause enzym...

Pancreatic β-cell glutaminase 2 maintains glucose homeostasis under the condition of hyperglycaemia.

Hanna Deguchi-Horiuchi Sawako Suzuki Eun Young Lee Takashi Miki Noriko Yamanaka Ichiro Manabe Tomoaki Tanaka Koutaro Yokote

Scientific reports 13(1) 7291-7291 2023年5月 [査読有り]

Glutaminase 2 (GLS2), a master regulator of glutaminolysis that is induced by p53 and converts glutamine to glutamate, is abundant in the liver but also exists in pancreatic β-cells. However, the roles of GLS2 in islets associated with glucose met...

ダウンロード

Liver group 2 innate lymphoid cells regulate blood glucose levels through IL-13 signaling and suppression of gluconeogenesis.

Masanori Fujimoto Masataka Yokoyama Masahiro Kiuchi Hiroyuki Hosokawa Akitoshi Nakayama Naoko Hashimoto Ikki Sakuma Hidekazu Nagano Kazuyuki Yamagata Fujimi Kudo Ichiro Manabe Eunyoung Lee Ryo Hatano Atsushi Onodera Kiyoshi Hirahara Koutaro Yokote Takashi Miki Toshinori Nakayama Tomoaki Tanaka

Nature communications 13(1) 5408-5408 2022年9月 [査読有り]

The liver stores glycogen and releases glucose into the blood upon increased energy demand. Group 2 innate lymphoid cells (ILC2) in adipose and pancreatic tissues are known for their involvement in glucose homeostasis, but the metabolic contributi...

ダウンロード

GLS2 is a tumor suppressor and a regulator of ferroptosis in hepatocellular carcinoma.

Carol Prives Sawako Suzuki Divya Venkatesh Hiroaki Kanda Akitoshi Nakayama Hiroyuki Hosokawa Eunyoung Lee Takashi Miki Brent R Stockwell Koutaro Yokote Tomoaki Tanaka

Cancer research 82(18) 3209-3222 2022年7月 [査読有り]

Glutamine synthase 2 (GLS2) is a key regulator of glutaminolysis and has been previously implicated in activities consistent with tumor suppression. Here we generated Gls2 knockout (KO) mice that develop late-occurring B cell lymphomas and hepatoc...