星野忠次

研究者氏名	星野忠次
	ホシノチュウジ
URL	https://www.p.chiba-u.jp/lab/riron/index.html
所属	千葉大学
部署	大学院薬学研究院
職名	准教授
学位	博士(工学(早稲田大学)
J-Global ID	200901091415976961

研究分野

ライフサイエンス / 薬系分析、物理化学 /

論文

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The Link of mRNA and rRNA Transcription by PUF60/FIR through TFIIH/P62 as a Novel Therapeutic Target for Cancer.

Kouichi Kitamura Tyuji Hoshino Atsushi Okabe Masaki Fukuyo Bahityar Rahmutulla Nobuko Tanaka Sohei Kobayashi Tomoaki Tanaka Takashi Shida Mashiro Ueda Toshinari Minamoto Hisahiro Matsubara Atsushi Kaneda Hideshi Ishii Kazuyuki Matsushita

International journal of molecular sciences 24(24) 2023年12月

The interaction between mRNA and ribosomal RNA (rRNA) transcription in cancer remains unclear. RNAP I and II possess a common N-terminal tail (NTT), RNA polymerase subunit RPB6, which interacts with P62 of transcription factor (TF) IIH, and is a c...

<i>In Silico</i> Identification of Inhibitory Compounds for SARS-Cov-2 Papain-Like Protease

Kazunori Miwa Yan Guo Masayuki Hata Yoshinori Hirano Norio Yamamoto Tyuji Hoshino

Chemical and Pharmaceutical Bulletin 71(12) 897-905 2023年12月

Sticklac-Derived Natural Compounds Inhibiting RNase H Activity of HIV-1 Reverse Transcriptase.

Yuma Ito Huiyan Lu Mariko Kitajima Hayato Ishikawa Yoshihiro Nakata Yasumasa Iwatani Tyuji Hoshino

Journal of natural products 86(11) 2487-2495 2023年11月

The emergence of drug-resistant viruses is a serious concern in current chemotherapy for human immunodeficiency virus type-1 (HIV-1) infectious diseases. Hence, antiviral drugs aiming at targets that are different from those of approved drugs are ...

Combinational antibody detection approach increases the clinical validity of colorectal cancer screening.

Sohei Kobayashi Takaki Hiwasa Kouichi Kitamura Masayuki Kano Tyuji Hoshino Sho Hirano Mayuko Hashimoto Masanori Seimiya Hideaki Shimada Fumio Nomura Hisahiro Matsubara Kazuyuki Matsushita

Journal of clinical laboratory analysis e24978 2023年11月

BACKGROUND: At different stages of the disease, biomarkers can help to determine disease progression and recurrence and provide a personalized indicator of therapeutic effectiveness. The serological identification of antigens by recombinant cDNA e...

The C-terminal tail of Rad17, iVERGE, binds the 9‒1‒1 complex independently of AAA+ ATPase domains to provide another clamp-loader interface.

Yasunori Fukumoto Tyuji Hoshino Yuji Nakayama Yasumitsu Ogra

DNA repair 130 103567-103567 2023年10月

The ATR pathway plays a crucial role in maintaining genome integrity as the major DNA damage checkpoint. It also attracts attention as a therapeutic target in cancer treatment. The Rad17-RFC2-5 complex loads the Rad9-Hus1-Rad1 (9-1-1) DNA clamp co...