星野忠次

研究者氏名	星野忠次
	ホシノチュウジ
URL	https://www.p.chiba-u.jp/lab/riron/index.html
所属	千葉大学
部署	大学院薬学研究院
職名	准教授
学位	博士(工学(早稲田大学)
J-Global ID	200901091415976961

研究分野

ライフサイエンス / 薬系分析、物理化学 /

論文

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Analysis of Binding Modes of Antigen-Antibody Complexes by Molecular Mechanics Calculation.

Liang Qu Xinyue Qiao Fei Qi Noritaka Nishida Tyuji Hoshino

Journal of chemical information and modeling 61(5) 2396-2406 2021年5月

Antibodies are one of the most important protein molecules in biopharmaceutics. Due to the recent advance in technology for producing monoclonal antibodies, many structural data are available on the antigen-antibody complexes. To characterize the ...

Assessing the Potency of β-Lactamase Inhibitors with Diverse Inactivation Mechanisms against the PenA1 Carbapenemase from Burkholderia multivorans.

Michiyoshi Nukaga Michael J Yoon Magdalena A Taracilia Tyuji Hoshino Scott A Becka Elise T Zeiser Joseph R Johnson Krisztina M Papp-Wallace

ACS infectious diseases 7(4) 826-837 2021年4月

Burkholderia cepacia complex (Bcc) poses a serious health threat to people with cystic fibrosis or compromised immune systems. Infections often arise from Bcc strains, which are highly resistant to many classes of antibiotics, including β-lactams....

Augmentative molecular aspect for phase inversion of vancomycin hydrochloride-loaded fatty acid in situ forming matrices

Takron Chantadee Jitnapa Sirirak Tyuji Hoshino Thawatchai Phaechamud

Materials and Design 199 2021年2月

Fatty acid-based in situ forming systems that carry vancomycin HCl (VCM) have been developed to treat local Gram-positive infections. However, little is known about mechanistic formation of fat-based in situ forming matrices. In this study, VCM-lo...

Anti-FIRΔexon2 autoantibody as a novel indicator for better overall survival in gastric cancer.

Sohei Kobayashi Takaki Hiwasa Takayuki Ishige Masayuki Kano Tyuji Hoshino Bahityar Rahmutulla Masanori Seimiya Hideaki Shimada Fumio Nomura Hisahiro Matsubara Kazuyuki Matsushita

Cancer science 112(2) 847-858 2021年2月

There is no clinically available biomarker for efficiently indicating the overall survival or therapy response of gastric cancer (GC). The autoantibodies (Abs) in the sera of anti-far-upstream element-binding protein-interacting repressor-lacking ...

Identification of the Inhibitory Compounds for Metallo-β-lactamases and Structural Analysis of the Binding Modes.

Taichi Kamo Keiichi Kuroda Shota Kondo Usaki Hayashi Satoshi Fudo Tomoki Yoneda Akiko Takaya Michiyoshi Nukaga Tyuji Hoshino

Chemical & pharmaceutical bulletin 69(12) 1179-1183 2021年

Metallo-β-lactamases (MBLs) are significant threats to humans because they deteriorate many kinds of β-lactam antibiotics and are key enzymes responsible for multi-drug resistance of bacterial pathogens. As a result of in vitro screening, two comp...

MISC

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FIR Δ exon2を選択的に阻害する分子化合物BK697は肝癌細胞の増殖を抑制する

鵜沼春菜志田隆史植田真白小林崇平星野忠次松下一之松下一之

医療検査と自動化(Web) 46(4) 2021年

胃癌における全生存期間を改善するための新しい指標としての抗-FIRΔexon2自己抗体

Kobayashi Sohei Kobayashi Sohei Hiwasa Takaki Ishige Takayuki Kano Masayuki Hoshino Tyuji Rahmutulla Bahityar Seimiya Masanori Shimada Hideaki Nomura Fumio Matsubara Hisahiro Matsushita Kazuyuki

Cancer Science (Web) 112(2) 2021年

遺伝性血管性浮腫の新規遺伝子変異分子動力学シミュレーションを用いた立体構造解析による病原性の検討

宮地秀明松岡悠美松江弘之星野忠次宇津野恵美松下一之橋村知波堀内孝彦

日本皮膚科学会雑誌 129(4) 595-596 2019年4月

In silico手法を利用した特異体質薬物毒性に関与するHLA多型の構造的解析

渡邉賢治青木重樹後藤貴博 QU Liang 星野忠次伊藤晃成

日本免疫毒性学会学術年会講演要旨集 25th 2018年

c‐Myc制御,DNA損傷修復,癌代謝に関わるFIRに着目した消化器・難治がんの診断法および包括的がん治療法の開発

松下一之星野忠次西村基北村浩一小林崇平グザヌルアリキン田中信子

金沢大学がん進展制御研究所がんの転移・薬剤耐性に関わる先導的研究拠点 2017 163 2018年