Cryptococcus deneoformans is a yeast-type fungus that causes fatal meningoencephalitis in immunocompromised patients and evades phagocytic cell elimination through an escape mechanism. Memory T (Tm) cells play a central role in preventing the reac...
Fábio S.Y. Yoshikawa   Maki Wakatsuki   Kosuke Yoshida   Rikio Yabe   Shota Torigoe   Sho Yamasaki   Glen N. Barber   Shinobu Saijo   
Journal of Innate Immunity 1-15 Jan 2023
<i>Aspergillus fumigatus</i> is a ubiquitous, yet potentially pathogenic, mold. The immune system employs innate receptors, such as dectin-1, to recognize fungal pathogens, but the immunological networks that afford protection are poor...
IL-17 plays important roles in host defense against Candida albicans at barrier surfaces and during invasive infection. However, the role of IL-17 in host defense after colonization of the epidermis, a main site of C. albicans infection...
Yulia Makusheva   Soo-Hyun Chung   Aoi Akitsu   Natsumi Maeda   Takumi Maruhashi   Xiao-Qi Ye   Tomonori Kaifu   Shinobu Saijo   Haiyang Sun   Wei Han   Ce Tang   Yoichiro Iwakura   
Experimental animals Feb 2022
Clec1A, a member of C-type lectin receptor family, has a carbohydrate recognition domain in its extracellular region, but no known signaling motif in the cytoplasmic domain. Clec1a is highly expressed in endothelial cells and weakly in dendritic c...