西城忍

研究者氏名	西城忍

URL
所属	千葉大学
部署	真菌医学研究センター
職名
J-Global ID	202001017026038525

研究分野

ライフサイエンス / 免疫学 /

論文

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Dectin-1 Plays an Important Role in House Dust Mite-Induced Allergic Airway Inflammation through the Activation of CD11b+ Dendritic Cells.

Ito T Hirose K Norimoto A Tamachi T Yokota M Saku A Takatori H Saijo S Iwakura Y Nakajima H

Journal of immunology (Baltimore， Md. : 1950) 198(1) 61-70 2017年1月

Dectin-1 Plays an Important Role in House Dust Mite-Induced Allergic Airway Inflammation through the Activation of CD11b(+) Dendritic Cells

Takashi Ito Koichi Hirose Ayako Norimoto Tomohiro Tamachi Masaya Yokota Aiko Saku Hiroaki Takatori Shinobu Saijo Yoichiro Iwakura Hiroshi Nakajima

JOURNAL OF IMMUNOLOGY 198(1) 61-70 2017年1月 [査読有り]

It is well known that sensitization against fungi is closely associated with severity of asthma. Dectin-1 (gene symbol Clec7a), a C-type lectin receptor, recognizes the fungal cell wall component beta-glucan, as well as some component(s) in house ...

The innate immune receptor Dectin-2 mediates the phagocytosis of cancer cells by Kupffer cells for the suppression of liver metastasis

Yoshitaka Kimura Asuka Inoue Sho Hangai Shinobu Saijo Hideo Negishi Junko Nishio Sho Yamasaki Yoichiro Iwakura Hideyuki Yanai Tadatsugu Taniguchi

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 113(49) 14097-14102 2016年12月 [査読有り]

Tumor metastasis is the cause of most cancer deaths. Although metastases can form in multiple end organs, the liver is recognized as a highly permissive organ. Nevertheless, there is evidence for immune cell-mediated mechanisms that function to su...

Dectin-2 Recognizes Mannosylated O-antigens of Human Opportunistic Pathogens and Augments Lipopolysaccharide Activation of Myeloid Cells

Alexandra Wittmann Dimitra Lamprinaki Kristian M. Bowles Ewa Katzenellenbogen Yuriy A. Knirel Chris Whitfield Takashi Nishimura Naoki Matsumoto Kazuo Yamamoto Yoichiro Iwakura Shinobu Saijo Norihito Kawasaki

JOURNAL OF BIOLOGICAL CHEMISTRY 291(34) 17629-17638 2016年8月 [査読有り]

LPS consists of a relatively conserved region of lipid A and core oligosaccharide and a highly variable region of O-antigen polysaccharide. Whereas lipid A is known to bind to the Toll-like receptor 4 (TLR4)-myeloid differentiation factor 2 (MD2) ...

Dectin-1 and Dectin-2 promote control of the fungal pathogen Trichophyton rubrum independently of IL-17 and adaptive immunity in experimental deep dermatophytosis

Fabio S. Y. Yoshikawa Rikio Yabe Yoichiro Iwakura Sandro R. de Almeida Shinobu Saijo

INNATE IMMUNITY 22(5) 316-324 2016年7月 [査読有り]

Dermatophytoses are chronic fungal infections, the main causative agent of which is Trichophyton rubrum (T. rubrum). Despite their high occurrence worldwide, the immunological mechanisms underlying these diseases remain largely unknown. Here, we u...