Tomoyuki Sato   Akinori Takemura   Kousei Ito   
Toxicology and applied pharmacology 427 115659-115659 2021年9月
Mitochondrial injury contributes to severe drug-induced liver injury. Particularly, mitochondrial permeability transition (MPT) is thought to be relevant to cytolytic hepatitis. However, the mechanism of drug-induced MPT is unclear and prediction ...
Akinori Takemura   Simin Gong   Tomoyuki Sato   Moemi Kawaguchi   Shuichi Sekine   Yasuhiro Kazuki   Toru Horie   Kousei Ito   
Journal of pharmaceutical sciences 110(9) 3306-3312 2021年9月 [査読有り]
Mitochondrial toxicity is an important factor to predict drug-induced liver injury (DILI). Previous studies have focused predominantly on mitochondrial toxicities due to parent forms, and no study has adequately evaluated metabolite-induced mitoch...
In drug development, a system for predicting drug metabolism and drug-induced toxicity is necessary to ensure drug safety. Cytochrome P450 family 3 subfamily A member 4 (CYP3A4) is an important drug-metabolizing enzyme expressed in the liver and s...
Yugo Ikeyama   Tomoyuki Sato   Akinori Takemura   Shuichi Sekine   Kousei Ito   
Toxicology in vitro : an international journal published in association with BIBRA 65 104785-104785 2020年6月 [査読有り]
Mitochondrial toxicity is a factor of drug-induced liver injury. Previously, we reported an in vitro rat hepatocyte assay where mitochondrial toxicity was more sensitively evaluated, using sugar resource substitution and increased oxygen supply. A...
Yugo Ikeyama   Tomoyuki Sato   Akinori Takemura   Shuichi Sekine   Kousei Ito   
Toxicology in vitro : an international journal published in association with BIBRA 67 104889-104889 2020年5月 [査読有り]
Recently, mitochondrial dysfunction is thought of as an important factor leading to a drug-induced liver injury. Our previous reports show that mitochondria-related toxicity, including respiratory chain inhibition (RCI) and reactive oxygen species...