Takeshi Haraguchi   Yuka Ozaki   Hideo Iba   
NUCLEIC ACIDS RESEARCH 37(6) e43 2009年4月 [査読有り]
Whereas the strong and stable suppression of specific microRNA activity would be essential for the functional analysis of these molecules, and also for the development of therapeutic applications, effective inhibitory methods to achieve this have ...
We report that a DBHS (Drosophila behaviour, human splicing) family protein, p54(nrb), binds both BRG1 (Brahma-related gene 1) and Brm (Brahma), catalytic subunits of the SWI/SNF (switch/sucrose non-fermentable) chromatin remodelling complex, and ...
CANCER RESEARCH 67(22) 10727-10735 2007年11月 [査読有り]
The mammalian SWI/SNF chromatin remodeling complex, an essential epigenetic regulator, contains either a single Brm or BRG1 molecule as its catalytic subunit. We observed frequent loss of Brm expression but not of BRG1 in human gastric cancer cell...
Takeshi Haraguchi   Taketoshi Mizutani   Nobutake Yamamichi   Taiji Ito   Shigeru Minoguchi   Hideo Iba   
FEBS LETTERS 581(25) 4949-4954 2007年10月 [査読有り]
RNA-dependent transcriptional silencing (RdTS) has been reported to operate even in human cell lines. It is tempting to speculate that RdTS plays a role in retroviral gene silencing, considering that retroviral RNA transcripts harbor a U3 promoter...
Watanabe H   Mizutani T   Haraguchi T   Yamamichi N   Minoguchi S   Yamamichi-Nishina M   Mori N   Kameda T   Sugiyama T   Iba H