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大学院薬学研究院

Researcher List >> Hiroto Hatakeyama
 

Hiroto Hatakeyama

 
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NameHiroto Hatakeyama
URLhttp://kaken.nii.ac.jp/d/r/70504786.ja.html
AffiliationChiba University
SectionGraduate School of Pharmaceutical Sciences
Job titleProfessor
Degree博士(薬学)(北海道大学)
J-Global ID201301040785601508

Research Interests

 
免疫チェックポイント阻害剤 ,抗体医薬 ,siRNA ,がん治療 ,核酸医薬 ,miRNA ,細胞内動態制御 ,ドラッグデリバリー ,ドラッグデリバリーシステム ,抗腫瘍効果

Research Areas

 
  • Life sciences / Tumor biology / 
  • Life sciences / Pharmacology / 
  • Life sciences / Pharmaceuticals - health and biochemistry / 
  • Life sciences / Clinical pharmacy / 

Research History

 
Apr 2022
 - 
Today
Chiba University Graduate School of Pharmaceutical Sciences Professor 
 
Oct 2019
 - 
Mar 2022
Chiba University Graduate School of Pharmaceutical Sciences Associate Professor 
 
Jan 2016
 - 
Sep 2019
Chiba University, Faculty of Pharmaceutical Sciences Laboratory of Clinical Pharmacology and Pharmacometrics Assistant Professor 
 
Oct 2013
 - 
Jan 2016
The University of Texas MD Anderson Cancer Center Department of Gynecologic Oncology and Reproductive Medicine Postdoctoral Fellow 
 
Oct 2013
 - 
Sep 2015
日本学術振興会海外特別研究員   
 

Committee Memberships

 
Jul 2023
 - 
Today
日本DDS学会  評議員
 
Jun 2023
 - 
Today
日本毒性学会  評議員
 
Nov 2022
 - 
Today
日本薬物動態学会  DDS DIS委員
 
Apr 2020
 - 
Today
日本薬剤学会  代議員
 
Feb 2017
 - 
Nov 2022
日本薬物動態学会  PMx-1 DIS委員
 

Awards

 
May 2020
日本薬剤学会, 2020年度奨励賞
 
Jul 2019
医療薬学フォーラム2019/第27回クリニカルファーマシーシンポジウム, 優秀ポスター賞,抗PD-1抗体と抗PD-L1抗体は同等か―マウスモデルを用いた動態と薬効の比較解析
畠山浩人 
 
Jul 2018
KJYSP Chair's Selection Award
畠山浩人 
 
Jul 2017
The Japan Society of Drug Delivery System, The Japan Society of Drug Delivery System Young Investigator's award
Hiroto Hatakeyama 
 
Mar 2017
The Pharmaceutical Society of Japan, The Pharmaceutical Society of Japan Award for Young Scientists,Development of a novel liposomal DDS by manipulating pharmacokinetics and intracellular trafficking for drug therapy and nucleic acid medicine
Hiroto Hatakeyama 
 

Papers

 
 
Jessica Anindita   Hiroki Tanaka   Takuma Yamakawa   Yuka Sato   Chika Matsumoto   Kota Ishizaki   Taiji Oyama   Satoko Suzuki   Keisuke Ueda   Kenjirou Higashi   Kunikazu Moribe   Kasumi Sasaki   Yumika Ogura   Etsuo Yonemochi   Yu Sakurai   Hiroto Hatakeyama   Hidetaka Akita   
Pharmaceutics   16(2)    Jan 2024
RNA vaccines are applicable to the treatment of various infectious diseases via the inducement of robust immune responses against target antigens by expressing antigen proteins in the human body. The delivery of messenger RNA by lipid nanoparticle...
 
Yi Liu   Miho Suzuoki   Hiroki Tanaka   Yu Sakurai   Hiroto Hatakeyama   Hidetaka Akita   
Biological & pharmaceutical bulletin   47(3) 698-707   2024
RNA vaccines based on Lipid nanoparticles (LNP) were put into practical use within only one year after the global outbreak of the coronavirus disease 2019 (COVID-19). This success of RNA vaccine highlights the utility of an mRNA delivery system as...
 
Jessica Anindita   Hiroki Tanaka   Ryotaro Oyama   Shinya Hagiwara   Daiki Shirane   Sakura Taneichi   Yuta Nakai   Kota Tange   Hiroto Hatakeyama   Yu Sakurai   Hidetaka Akita   
Pharmaceutics   15(12)    Nov 2023
Because of its efficient and robust gene transfer capability, messenger RNA (mRNA) has become a promising tool in various research fields. The lipid nanoparticle (LNP) is considered to be a fundamental technology for an mRNA delivery system and ha...
 
Mizuki Doi   Hiroki Tanaka   Takara Ohoto   Naoya Miura   Yu Sakurai   Hiroto Hatakeyama   Hidetaka Akita   
Small (Weinheim an der Bergstrasse, Germany)   e2205131   Jan 2023   [Refereed]
The reactivation of anticancer immunity is a fundamental principle in cancer immunotherapy as evidenced by the use of immune checkpoint inhibitors (ICIs). While treatment with the ICIs is shown to have remarkable and durable therapeutic effects in...
 
Masaki Gomi   Yu Sakurai   Minami Sato   Hiroki Tanaka   Yumi Miyatake   Koichi Fujiwara   Mizuki Watanabe   Satoshi Shuto   Yuta Nakai   Kota Tange   Hiroto Hatakeyama   Hidetaka Akita   
Advanced Healthcare Materials   2202528-2202528   Dec 2022   [Refereed]

Misc.

 
 
金森大誠   宮崎菜摘   青木重樹   伊藤晃成   樋坂章博   畠山浩人   
日本薬学会関東支部大会講演要旨集   65th (CD-ROM)    2021
 
Hiroto Hatakeyama   
56(8) 760-764   Aug 2020   [Refereed][Invited]
 
原島 秀吉   畠山 浩人   金沢 貴憲   
薬剤学: 生命とくすり   80(1) 13-23   Jan 2020   
 
Hiroto Hatakeyama   
79(2) 80-83   Feb 2019   [Invited]
 
32(4) 323-329   Sep 2017   [Invited]

Books and Other Publications

 
 
Khalil IA, Hatakeyama H, Nakamura T, Harashima H(Part:Contributor, A Multifunctional Envelope-type Nano Device for Cancer Therapy)
Springer   2019   (ISBN:9784431568803)   [Refereed]
This book proposes the importance of new systems of drug design and delivery based on cancer pathophysiology in addition to cancer molecular and cellular biology. The current studies based on molecular and cellular biology while ignoring pathophys...

Teaching Experience

 
Apr 2022
 - 
Today
臨床薬物動態学
Apr 2022
 - 
Today
物理化学IV
Apr 2022
 - 
Today
薬剤学IV
2016
 - 
Today
薬物治療学II
2016
 - 
Today
臨床薬理学

Professional Memberships

 
 
   
 
日本がん免疫学会
 
   
 
THE JAPANESE SOCIETY FOR THE STUDY OF XENOBIOTICS
 
   
 
American Association for Cancer Research
 
   
 
THE JAPANESE CANCER ASSOCIATION
 
   
 
THE ACADEMY OF PHARMACEUTICAL SCIENCE AND TECHNOLOGY, JAPAN

Research Projects

 
 
腹腔内移行経路による腫瘍微小環境編集と難治性腹膜播種治療への展開
日本学術振興会: 科学研究費助成事業 基盤研究(B)
畠山 浩人 佐野 誠 
Project Year: Apr 2022 - Mar 2026
 
免疫チェックポイント阻害剤に対する抗薬物抗体産生のダイバーシティの解明
文部科学省: 学術変革領域研究(A) 「物質共生」公募研究
Project Year: Oct 2021 - Mar 2023
 
Project Year: Apr 2019 - Mar 2022
 
Model based meta-analysis and establishment of PBPK model for appropriate use of factor Xa inhibitor
Japan Society for the Promotion of Science: Grants-in-Aid for Scientific Research
Sato Hiromi 
Project Year: Apr 2017 - Mar 2020
 
がん細胞および腫瘍微小環境の温熱耐性応答メカニズムの解明
文部科学省: 新学術領域研究「温度生物学」公募研究
畠山浩人 
Project Year: Apr 2018 - Mar 2020

Industrial Property Rights

 
 
丹下耕太   新井将也   久保和弘   秋田英万   原島秀吉   畠山浩人   石破諒平   鵜川真実   田中浩揮