T. Mitamura   S. Pradeep   M. McGuire   S. Y. Wu   S. Ma   H. Hatakeyama   Y. A. Lyons   T. Hisamatsu   K. Noh   A. Villar-Prados   X. Chen   C. Ivan   C. Rodriguez-Aguayo   W. Hu   G. Lopez-Berestein   R. L. Coleman   A. K. Sood   
Oncogene 37(6) 722-731 2018年2月 [査読有り]
Anti-vascular endothelial growth factor (VEGF) therapy has demonstrated efficacy in treating human metastatic cancers, but therapeutic resistance is a practical limitation and most tumors eventually become unresponsive. To identify microenvironmen...
Biological and Pharmaceutical Bulletin 41(4) 619-627 2018年 [査読有り]
Acquired resistance to sunitinib is a challenge in the treatment of renal cell carcinoma (RCC). The dys-regulation of cellular metabolism is prevalent during resistance acquisition. It is known that in sunitinib-resistant RCC 786-O (786-O Res) cel...
JOURNAL OF PHARMACEUTICAL SCIENCES 106(9) 2771-2779 2017年9月 [査読有り]
In this study, intestinal drug-drug interactions (DDIs) for substrate drugs of P-glycoprotein were simulated extensively using the extended Q(Gut) model and translocation model to explore the determinants of DDI. The results of analyses using both...
CHEMICAL & PHARMACEUTICAL BULLETIN 65(7) 612-617 2017年7月 [査読有り]
Significant progress has been achieved in the development of stimuli-responsive nanocarriers for drug delivery, diagnosis, and therapy. Various types of triggers are utilized in the development of nanocarrier delivery. Endogenous factors such as c...
Khalil IA, Hatakeyama H, Nakamura T, Harashima H(担当:分担執筆, 範囲:A Multifunctional Envelope-type Nano Device for Cancer Therapy)
Springer 2019年 (ISBN:9784431568803) [査読有り]
This book proposes the importance of new systems of drug design and delivery based on cancer pathophysiology in addition to cancer molecular and cellular biology. The current studies based on molecular and cellular biology while ignoring pathophys...